Pediococcus pentosaceus MAK99P15P and Improved Gut Microbiome Composition

• Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish

  • 2023-02-01
  • Clinical Trial
  • Frontiers in Nutrition 10
  • • Yue Liu
    • D-L Zhu
    • Jiwen Liu
    • X. Sun
    • Feng Gao
    • Hui-Ping Duan
    • Lina Dong
    • Xin Wang
    • Changxing Wu

  • PubMed: 36819708
  • DOI: 10.3389/fnut.2023.1087703

  15 Insights on

  • Improved Gut Microbiome Composition

  • Low evidence
  • Animal Study

  *P. pentosaceus* PR-1 improved gut health by decreasing the abundance of *Ralstonia* and *Aeromonas* which were increased induced by HFD.

  Effect

  Beneficial

  Effect size

  Moderate

• New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism

  • 2020-10-28
  • RCT · n = 28
  • World Journal of Gastroenterology 26(40)
  • • Xianwan Jiang
    • Yating Li
    • Jian-zhong Ye
    • L. Lv
    • Liya Yang
    • Xiaoyuan Bian
    • Wen-rui Wu
    • Jingjing Wu
    • D. Shi
    • Qing Wang
    • D. Fang
    • Kaicen Wang
    • Qiangqiang Wang
    • Yanmeng Lu
    • Jiaojiao Xie
    • Lanjuan Li

  • PubMed: 33177795
  • DOI: 10.3748/wjg.v26.i40.6224

  9 Insights on

  • Improved Gut Microbiome Composition

  • Low evidence
  • Rigorous Journal
  • Animal Study

  In contrast, Pediococcus pentosaceus administration increased the microbial diversity, restored the relative abundance of Lactobacillus, Pediococcus, Prevotella, Clostridium and Akkermansia and increased propionic acid and butyric acid production by modifying SCFA-producing bacteria.

  Effect

  Beneficial

  Effect size

  Large

• Pediococcus pentosaceus LI05 alleviates DSS‐induced colitis by modulating immunological profiles, the gut microbiota and short‐chain fatty acid levels in a mouse model

  • 2020-05-03
  • Clinical Trial
  • Microbial Biotechnology 13(4)
  • • Xiaoyuan Bian
    • Liya Yang
    • Wen-rui Wu
    • L. Lv
    • Xianwan Jiang
    • Qing Wang
    • Jingjing Wu
    • Yating Li
    • Jianzhong Ye
    • D. Fang
    • D. Shi
    • Kaicen Wang
    • Qiangqiang Wang
    • Yanmeng Lu
    • Jiaojiao Xie
    • Jiafeng Xia
    • Lanjuan Li

  • PubMed: 32363766
  • DOI: 10.1111/1751-7915.13583

  8 Insights on

  • Improved Gut Microbiome Composition

  • Low evidence
  • Animal Study

  Furthermore, a significantly altered gut microbiota composition with increased diversity and short-chain fatty acid (SCFA) production was observed in mice treated with P. pentosaceus LI05.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes