Streptococcus salivarius M18 and Reduced Plaque Index

• Adjunctive use of Streptococcus salivarius M18 probiotic in the treatment of periodontitis: a randomized controlled trial.

  • 2025-05-28
  • RCT · n = 55
  • 3 Biotech 15(6)
  • • Wei-Ju Chen
    • Lavanya Ajay Sharma
    • Peng Shao
    • Tia Griffith
    • Robert Love
    • Rohit Jain
    • John Hale
    • Ajay Sharma

  • PubMed: 40443548
  • DOI: 10.1007/s13205-025-04363-w

  7 Insights on

  • Reduced Plaque Index

  • High evidence

  The test group demonstrated significantly improved PPD, BoP, and PI compared to the placebo group at post-treatment follow-ups

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  lozenges (dose not specified in abstract)

• Antigingivitis and Antiplaque Effects of Oral Probiotic Containing the Streptococcus salivarius M18 Strain: A Randomized Clinical Trial

  • 2023-09-06
  • RCT · n = 61
  • Nutrients 15(18)
  • • K. Babina
    • Dilara Salikhova
    • V. Doroshina
    • Irina Makeeva
    • A. Zaytsev
    • Matvey Uvarichev
    • M. Polyakova
    • N. Novozhilova

  • PubMed: 37764667
  • DOI: 10.3390/nu15183882

  7 Insights on

  • Reduced Plaque Index

  • High evidence

  Turesky modification of the Quigley and Hein Plaque Index, with the effect size of 0.55 [95%CI: 0.02-1.07], in the probiotic group after the intervention.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes