Pernicious anemia (PA) is a condition where the body cannot absorb vitamin B12 effectively due to a lack of intrinsic factor, a protein necessary for the absorption of vitamin B12 in the ileum of the small intestine¹. Because of this malabsorption, traditional oral vitamin B12 supplements are typically ineffective for individuals with PA.

Liposomal formulations, like liposomal methylcobalamin, are designed to enhance the absorption of nutrients by encapsulating them in liposomes, which can potentially bypass some of the limitations of the digestive system by improving absorption through cell membranes². However, there is limited direct evidence on the efficacy of liposomal B12 formulations specifically for individuals with pernicious anemia.

While liposomal versions may offer some increased absorption potential compared to traditional oral supplements, individuals with pernicious anemia generally require direct administration methods like injections to ensure adequate levels of B12. Injections deliver B12 directly into the bloodstream, bypassing the need for gut absorption, making them the standard treatment for ensuring proper B12 levels in PA¹.

If you are considering attempting a liposomal supplement, it is essential to discuss this with a healthcare provider to ensure it aligns with your specific health needs and to monitor your B12 levels closely.

Footnotes

1. NCBI Bookshelf StatPearls - Vitamin B12 (Cobalamin) ↩ ↩²

2. Summary from authoritative sources on potential benefits of liposomal formulations in nutrient delivery. ↩