To increase nitric oxide (NO) levels in the body, certain dietary supplements can be particularly effective. NO is crucial for various bodily functions including blood vessel dilation, improved muscle performance, and enhanced exercise capacity. Here's a detailed look at some supplements that can help boost nitric oxide levels:

Key Supplements for Increasing Nitric Oxide

1. L-Arginine

   • Role: L-arginine is a direct precursor to nitric oxide synthesis.
   • Benefits: It improves blood flow, enhances exercise performance, and supports cardiovascular health¹².

2. L-Citrulline

   • Role: L-citrulline converts to L-arginine in the body, thus indirectly increasing nitric oxide production.
   • Benefits: It improves exercise performance, muscle recovery, and overall endurance. Citrulline malate, a combination of L-citrulline and malate, is particularly noted for enhancing ATP production¹²³.

3. Beetroot Juice

   • Role: Rich in dietary nitrates which are converted to nitric oxide in the body via an NO synthase-independent pathway.
   • Benefits: It enhances cardiorespiratory endurance, increases time to exhaustion during exercise, and mitigates the effects of hypoxia³⁴.

4. Glycine Propionyl-L-Carnitine (GPLC)

   • Role: A compound that not only enhances nitric oxide production but also supports muscle energy.
   • Benefits: It can improve muscle strength, reduce muscle fatigue, and increase endurance².

5. 2-(Nitroxy) Ethyl 2-Amino-3-Methylbutanoate

   • Role: Acts as a nitric oxide donor to enhance NO synthesis.
   • Benefits: Improves blood flow and might have synergistic effects on muscle performance and endurance¹.

Considerations

• Side Effects: Some supplements may cause side effects such as gastrointestinal discomfort, headaches, or palpitations. It's recommended to start with smaller or divided doses to mitigate these issues¹².
• Medical Supervision: Always consult with a healthcare provider before starting any new supplement, especially if you have pre-existing health conditions or are on medication.

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Footnotes

1. AYSHA KARIM KIANI, Dietary supplements for improving nitric-oxide synthesis, 2022 ↩ ↩² ↩³ ↩⁴

2. Adam M. Gonzalez, Supplementation with Nitric Oxide Precursors for Strength Performance: A Review of the Current Literature, 2023 ↩ ↩² ↩³ ↩⁴

3. Lewis A. Gough, A critical review of citrulline malate supplementation and exercise performance, 2021 ↩ ↩²

4. Raúl Domínguez, Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review, 2017 ↩