Nicotinamide Mononucleotide (NMN) is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), an essential coenzyme in the body that plays a crucial role in energy metabolism, DNA repair, and the activation of sirtuins, a family of proteins that regulate cellular health¹². NAD+ levels tend to decline significantly with age, which can impact various physiological functions and contribute to age-related conditions³.

Benefits of NMN Supplementation:

1. Increases NAD+ Levels: NMN supplementation has been shown to elevate NAD+ levels, which can improve mitochondrial function and overall cellular health⁴.

2. Improves Metabolic Health: NMN helps in enhancing insulin sensitivity, reducing inflammation, and improving metabolic functions. This has been observed in both animal and human studies⁵⁶.

3. Anti-aging Effects: Studies indicate that NMN can delay aging markers, such as frailty, and can potentially extend lifespan, particularly in animal models⁷. It also supports DNA repair and genomic stability⁸.

4. Enhanced Physical Performance: NMN has been associated with improvements in physical performance, such as walking distance and muscle function, especially in older adults⁹.

5. Cognitive Benefits: Preliminary studies suggest that NMN may support cognitive functions and protect against neurodegenerative disorders, potentially by enhancing NAD+ levels in the brain¹⁰.

Safety and Tolerability:

NMN appears to be safe and well-tolerated in dosages up to 900 mg per day in humans, without significant adverse effects¹¹. However, more extensive and long-term clinical trials are necessary to fully understand its safety profile and efficacy.

Overall, NMN is a promising supplement for supporting aging and maintaining metabolic health, but ongoing research and clinical trials are essential to validate its benefits and long-term safety in humans.

Footnotes

1. Kane, A. E. (2021). Long-term NMN treatment increases lifespan and healthspan in mice in a sex-dependent manner. ↩

2. Shade, C. (2020). The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule. ↩

3. Rahman, S. U. (2024). Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging. ↩

4. Yi, L. (2022). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults. ↩

5. Soma, M. (2020). The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions. ↩

6. Nadeeshani, H. (2021). Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns. ↩

7. Igarashi, M. (2022). Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. ↩

8. Song, Q. (2022). The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. ↩

9. Shade, C. (2020). The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule. ↩

10. Song, Q. (2022). The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. ↩

11. Yi, L. (2022). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults. ↩