Sure, I'd be happy to help. What would you like to know about MSM with OptiMSM by Doctor's Best?

Methylsulfonylmethane (MSM) is generally considered safe for consumption under recommended dosages. Here's a summary of the safety findings:

1. General Safety:

   • MSM is a naturally occurring sulfur compound and has been used as a dietary supplement for several decades. It obtained Generally Recognized as Safe (GRAS) status in 2007^1^.
   • Studies have evaluated doses up to 6 grams per day and found no significant adverse effects on basic metabolic functions, including liver and kidney function, blood pressure, and blood cell counts^2^.

2. Side Effects:

   • Some people might experience mild side effects such as nausea, diarrhea, bloating, and stomach discomfort^3^.
   • When applied to the skin, MSM is possibly safe when used for up to 20 days with other ingredients like silymarin or hyaluronic acid and tea tree oil^3^.

3. Clinical Trials:

   • A randomized, double-blind, placebo-controlled trial with osteoarthritis patients demonstrated that MSM at dosages of up to 6 grams per day did not result in major adverse events and was well-tolerated^4^.
   • Additional studies have reviewed its usage for joint health and pain, showing positive results without significant safety concerns^5^.

In summary, MSM is generally safe for most individuals when taken within the recommended dosages. However, it is always best to consult with a healthcare provider before beginning any new supplement, especially if you have underlying health conditions or are taking other medications.