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Exploring Supplements and PT-141 for Enhancing Libido and Sexual Function

This discussion covers potential supplements like Ginseng, Maca, and Ginkgo Biloba for improving libido, and dives into PT-141 (Bremelanotide) for treating hypoactive sexual desire disorder, including its efficacy, administration methods, and safety considerations.


  • What supplements could improve libido?

  • Certain supplements have shown potential in improving libido based on preliminary research. Here are some of the most commonly referenced:

    1. Ginseng: Particularly Korean Red Ginseng, has been traditionally used to enhance sexual function and has shown some positive effects in research studies1.
    2. Maca: A root vegetable from Peru, often called "Peruvian ginseng," which may help with sexual desire and performance1.
    3. Ginkgo Biloba: Known for its positive effects on circulation, Ginkgo Biloba may help with sexual function due to improved blood flow2.

    Other supplements such as saw palmetto, while sometimes claimed to enhance libido, lack strong scientific backing for these claims2. Always consult with a healthcare provider before starting any new supplement, especially if there are underlying health conditions or other medications being taken.

    Footnotes

    1. Sabna Kotta, "Exploring scientifically proven herbal aphrodisiacs," PMC, 2012. 2

    2. Dana Sparks, "Home Remedies: Do natural aphrodisiacs work?" Mayo Clinic News Network, 2018. 2

  • What about PT-141 ?

  • PT-141, also known as Bremelanotide, is a melanocortin receptor agonist used to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. It works by activating melanocortin pathways in the brain that influence sexual responses, which sets it apart from other treatments like PDE-5 inhibitors (e.g., sildenafil) that target vascular components of erectile dysfunction123.

    Efficacy and Administration:

    • PT-141 can be administered as a subcutaneous injection or intranasally.
    • The typical dosage is 1.75 mg injected subcutaneously about 45 minutes before anticipated sexual activity.
    • Clinical studies have demonstrated its effectiveness in improving sexual desire and reducing distress associated with low libido in women14.

    Safety and Side Effects:

    • Common side effects include nausea, flushing, and headache1.
    • It is contraindicated in individuals with uncontrolled hypertension or cardiovascular disease due to potential effects on blood pressure and heart rate2.
    • Long-term studies have shown it to be safe with sustained efficacy for HSDD4.

    The use of PT-141 in men for sexual dysfunction has also been explored, although it is not currently approved for this use. Studies have shown promising results for male erectile dysfunction, specifically in cases non-responsive to traditional treatments15.

    Footnotes

    1. Anita H Clayton, "Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women: A Randomized, Placebo-Controlled Dose-Finding Trial," PMC, 2016. 2 3 4

    2. Amber N. Edinoff, "Bremelanotide for Treatment of Female Hypoactive Sexual Desire," PMC, 2022. 2

    3. Mayo Clinic, "Bremelanotide (Subcutaneous Route) Side Effects," Mayo Clinic.

    4. James A. Simon, "Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder," PMC, 2019. 2

    5. Stephen H. King, "Melanocortin Receptors, Melanotropic Peptides and Penile Erection," PMC.

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