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A diet rich in oat bran improves blood lipids and hemostatic factors, and reduces apparent energy digestibility in young healthy volunteers.

  • 2011-06-08
  • European journal of clinical nutrition 65(9)
    • M Kristensen
    • S Bügel

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 24
Population
24 adults (age 25.2±2.7 years; body mass index: 24.9±2.9 kg/m2)
Methods
double-blind, randomized crossover study, two 2-week dietary intervention periods: low-fiber diet (control) or an oat bran (control +102 g oat bran/day) diet
Blinding
Double-blind
Duration
2 weeks
Funding
Unclear
  • Rigorous Journal

Background/objectives

Oat bran shows cholesterol-lowering properties, but its effects on other cardiovascular risk markers are less frequently investigated. This study examined the effects of oat bran on blood lipids, hemostatic factors and energy utilization.

Subjects/methods

A double-blind, randomized crossover study in 24 adults (age 25.2±2.7 years; body mass index: 24.9±2.9 kg/m2), who completed two 2-week dietary intervention periods: low-fiber diet (control) or an oat bran (control +102 g oat bran/day) diet. Fasting blood samples were drawn before and after each period, and 3-day fecal samples were collected during the last week of each period.

Results

Total cholesterol decreased by 14% during the oat bran period compared with 4% during the control period (P<0.001). Non-high-density lipoprotein (HDL) cholesterol decreased by 16% in the oat bran period compared with 3% in the control period (P<0.01), as did total triacylglycerol (21 vs 10%, P<0.05) and very-low-density lipoprotein triacylglycerol 33 vs 9%, P<0.01). Plasminogen activator inhibitor-1 (PAI-1) and factor VII (fVII) levels decreased more during consumption of oat bran compared with the control period (PAI-1: 30 vs 2.3%, P<0.01; fVII: 15 vs 7.6%, <0.001). Fecal volume and dry matter were greater when consuming the oat bran diet compared with the control (P<0.001), and energy excretion was increased by 37% (1014 vs 638 kJ/day, P<0.001); however, changes in body weight did not differ (oat bran:-0.3±0.5 kg; control: 0.0±0.7 kg).

Conclusions

Addition of oat bran (6 g soluble fiber/day) to a low-fiber diet lowered total and non-HDL cholesterol, as well as hemostatic factors, and may affect energy balance through reduced energy utilization.

Research Insights

  • Oat Bran→Increased Energy Excretion

    energy excretion was increased by 37% (1014 vs 638 kJ/day, P<0.001)

    Effect
    Neutral
    Effect size
    Small
    Dose
    102 g/day (6 g soluble fiber/day)
  • Oat Bran→Increased Fecal Output

    Fecal volume and dry matter were greater when consuming the oat bran diet compared with the control (P<0.001)

    Effect
    Neutral
    Effect size
    Small
    Dose
    102 g/day (6 g soluble fiber/day)
  • Oat Bran→Reduced Blood Cholesterol

    Total cholesterol decreased by 14% during the oat bran period compared with 4% during the control period (P<0.001).

    Effect
    Beneficial
    Effect size
    Large
    Dose
    102 g/day (6 g soluble fiber/day)
  • Oat Bran→Reduced Body Weight

    changes in body weight did not differ (oat bran:-0.3±0.5 kg; control: 0.0±0.7 kg)

    Effect
    Neutral
    Effect size
    Small
    Dose
    102 g/day (6 g soluble fiber/day)
  • Oat Bran→Reduced Factor VII

    factor VII (fVII) levels decreased more ... (fVII: 15 vs 7.6%, <0.001)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    102 g/day
  • Oat Bran→Reduced Non-HDL Cholesterol

    Non-high-density lipoprotein (HDL) cholesterol decreased by 16% in the oat bran period compared with 3% in the control period (P<0.01)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    102 g/day (6 g soluble fiber/day)
  • Oat Bran→Reduced Plasminogen Activator Inhibitor-1 Level

    Plasminogen activator inhibitor-1 (PAI-1) and factor VII (fVII) levels decreased more during consumption of oat bran compared with the control period (PAI-1: 30 vs 2.3%, P<0.01)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    102 g/day (6 g soluble fiber/day)
  • Oat Bran→Reduced Total Triacylglycerol

    total triacylglycerol (21 vs 10%, P<0.05)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    102 g/day (6 g soluble fiber/day)
  • Oat Bran→Reduced Triglyceride Level

    total triacylglycerol (21 vs 10%, P<0.05)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    102 g/day
  • Oat Bran→Reduced Tumor Necrosis Factor Alpha

    Plasminogen activator inhibitor-1 (PAI-1) and factor VII (fVII) levels decreased more during consumption of oat bran compared with the control period (PAI-1: 30 vs 2.3%, P<0.01;

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    102 g/day
  • Oat Bran→Reduced Uric Acid Levels

    factor VII (fVII) levels decreased more during consumption of oat bran compared with the control period (fVII: 15 vs 7.6%, <0.001)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    102 g/day (6 g soluble fiber/day)
  • Oat Bran→Reduced VLDL Triglyceride Level

    very-low-density lipoprotein triacylglycerol 33 vs 9%, P<0.01

    Effect
    Beneficial
    Effect size
    Large
    Dose
    102 g/day
  • Oat Bran→Reduced Very-Low-Density Lipoprotein Triglyceride Level

    very-low-density lipoprotein triacylglycerol 33 vs 9%, P<0.01)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    102 g/day (6 g soluble fiber/day)
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