Antihypertensive effects of Nigella sativa supplementation: An updated systematic review and meta-analysis of randomized controlled trials.
- 2023-06-21
- Phytotherapy research : PTR 37(8)
- Zeynab Kavyani
- Vali Musazadeh
- Ehsan Safaei
- Mina Mohammadi Asmaroud
- Fatemeh Khashakichafi
- Sana Sedgh Ahrabi
- Parvin Dehghan
- PubMed: 37341696
- DOI: 10.1002/ptr.7891
Study Design
- Type
- Meta-Analysis
- Methods
- Meta-analysis of randomized controlled trials; databases searched till August 2022; random-effects model for weighted mean differences; nonlinear dose-response analysis and meta-regression conducted
- Funding
- Unclear
Clinical studies have suggested that Nigella Sativa (N. sativa) supplementation may effectively reduce blood pressure, but the findings are controversial. Therefore, this study aimed to examine the effects of N. sativa on blood pressure in adults. PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar were searched till August 2022. To analyze weighted mean differences (WMDs), a random-effects model was utilized. Nonlinear dose-response analysis and a meta-regression were conducted. N. sativa supplementation was effective in reducing both systolic (WMD: -3.06 mmHg; 95% CI: -3.89 to -2.22, p < 0.001; I2 = 84.7%, p < 0.001) and diastolic blood pressure (WMD = -2.69 mmHg; 95% CI: -3.72, -1.66, p < 0.001; I2 = 97.3%, p < 0.001). The current meta-analysis suggests that N. sativa supplementation can improve blood pressure and claims that N. sativa could be used as an effective approach to blood pressure management.
Research Insights
and diastolic blood pressure (WMD = -2.69 mmHg; 95% CI: -3.72, -1.66, p < 0.001; I2 = 97.3%, p < 0.001).
- Effect
- Beneficial
- Effect size
- Small
N. sativa supplementation was effective in reducing both systolic (WMD: -3.06 mmHg; 95% CI: -3.89 to -2.22, p < 0.001; I2 = 84.7%, p < 0.001)
- Effect
- Beneficial
- Effect size
- Small