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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Black Cumin and Reduced Diastolic Blood Pressure

Doses used in studies

mg/day: 200–4,600 (median 2,400, IQR 200–4,600) — 1 study

Time to effect

Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 2 studies

2 of 2 papers

The Effect of Nigella sativa Supplementation on Cardiometabolic Health in Patients With Metabolic Diseases: A GRADE-Assessed Systematic Review and Meta-Analysis.
- 2026-03
- Meta-Analysis · n = 2,145
- Endocrinology, diabetes & metabolism 9(2)
- - Vali Musazadeh
  - Melika Jahangir
  - Mahsa Mahmoudinezhad
  - Amir Hossein Faghfouri
  - Farshad Teymoori
  - Ali Arash Anoushirvani
  - Mohsen Khaleghian
- PubMed: 41858302
- DOI: 10.1002/edm2.70207
7 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
DBP (WMD = -2.75 mmHg; 95% CI: -4.62, -0.89)
Effect
Beneficial
Effect size
Small
Significant
Yes
Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials.
- 2025-09
- Meta-Analysis · n = 5,026
- Pharmacological research 219
- - Ali Jafari
  - Helia Mardani
  - Amir Hossein Faghfouri
  - Zahra Mirzaei Fashtali
  - Mohtaram Hashemi
  - Matin Abdollahi Yousefabady
  - Reihane Javid
  - Sahar Golabi
  - Bahareh Arghavan
  - Vali Musazadeh
  - Mahshid Naghashpour
- PubMed: 40714301
- DOI: 10.1016/j.phrs.2025.107882
35 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
N. sativa supplementation significantly improved ... diastolic blood pressure (DBP)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
200 to 4600 mg/day