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Effect of Long-Term Taurine Supplementation on the Lipid and Glycaemic Profile in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.

  • 2024-12-27
  • Nutrients 17(1)
    • Qin Sun
    • Jieping Wang
    • Huanyu Wang
    • Hanhan Yu
    • Kang Wan
    • Fuyi Ma
    • Ru Wang

Study Design

Type
Meta-Analysis
Population
adults with overweight or obesity
Methods
Systematic review and meta-analysis of 9 RCTs; literature search up to October 2024; subgroup analyses by dosage and BMI category
  • Rigorous Journal

Background

Taurine has been demonstrated to regulate and improve metabolic health. However, physiological and pathological differences among individuals with overweight or obesity may result in varied responses to taurine supplementation. This study aims to estimate the effects of long-term taurine supplementation on blood lipids, glycemia, and insulin sensitivity in adults with overweight or obesity through a systematic review and meta-analysis.

Methods

The literature search was based on six databases (Web of Science, PubMed, Scopus, EMBASE, Cochrane, and SPORTDiscus) up to October 2024. Subgroup analyses were performed based on daily taurine intake dosage (<3 g or 3 g), overweight (BMI 25-29.9 kg/m2), and obesity (BMI ≥30 kg/m2).

Results

The final number of studies that met the inclusion criteria was 9 RCTs. The overall analysis showed that taurine supplementation significantly decreased TG (WMD = -0.56 mg/dL, 95% CI: -0.92 to -0.2, p = 0.002, I2 = 63%), TC (WMD = -0.71 mg/dL, 95% CI: -1.17 to -0.25, p = 0.002, I2 = 73%), and fasting insulin (WMD = -2.15 µU/mL, 95% CI: -3.24 to -1.06, p = 0.0001, I2 = 9%). In the subgroup analysis, long-term taurine intake led to BMI improvement in overweight adults (WMD = -1.14 kg/m2, 95% CI: -1.81 to -0.47, p = 0.0008, I2 = 0%). Meanwhile, improvements in HbA1c (WMD = -0.33%, 95% CI: -0.53 to -0.12, p = 0.002, I2 = 16%) and HOMA-IR (WMD = -0.91, 95% CI: -1.74 to -0.08, p = 0.003, I2 = 54%) were observed only in obese participants following taurine supplementation. Additionally, the long-term intake of 3 g of taurine significantly improved HbA1c (WMD = -0.37%, 95% CI: -0.61 to -0.13, p = 0.003, I2 = 0%) and FPG levels (WMD = -7.14 mg/dL, 95% CI: -12.53 to -1.74, p = 0.003, I2 = 70%) in overweight/obesity.

Conclusions

Long-term taurine supplementation is particularly effective in improving glycemic control and insulin sensitivity in obesity. Furthermore, higher doses of taurine (3 g per day) demonstrate even greater improvements in glycemic control.

Research Insights

  • Taurine→Improved Insulin Sensitivity

    improvements in ... HOMA-IR (WMD = -0.91, 95% CI: -1.74 to -0.08, p = 0.003, I² = 54%) were observed only in obese participants following taurine supplementation

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    variable (studies used <3 g/day or 3 g/day)
  • Taurine→Reduced Body Mass Index

    long-term taurine intake led to BMI improvement in overweight adults (WMD = -1.14 kg/m², 95% CI: -1.81 to -0.47, p = 0.0008, I² = 0%)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    variable (studies used <3 g/day or 3 g/day)
  • Taurine→Reduced Fasting Blood Glucose Levels

    long-term intake of 3 g of taurine significantly improved ... FPG levels (WMD = -7.14 mg/dL, 95% CI: -12.53 to -1.74, p = 0.003, I² = 70%) in overweight/obesity

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    3 g/day
  • Taurine→Reduced Hemoglobin A1c

    improvements in HbA1c (WMD = -0.33%, 95% CI: -0.53 to -0.12, p = 0.002, I² = 16%) were observed only in obese participants following taurine supplementation

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    3 g/day
  • Taurine→Reduced Insulin Levels

    taurine supplementation significantly decreased ... fasting insulin (WMD = -2.15 µU/mL, 95% CI: -3.24 to -1.06, p = 0.0001, I² = 9%)

    Effect
    Beneficial
    Effect size
    Large
    Dose
    variable (studies used <3 g/day or 3 g/day)
  • Taurine→Reduced Total Cholesterol

    taurine supplementation significantly decreased ... TC (WMD = -0.71 mg/dL, 95% CI: -1.17 to -0.25, p = 0.002, I² = 73%)

    Effect
    Beneficial
    Effect size
    Large
    Dose
    variable (studies used <3 g/day or 3 g/day)
  • Taurine→Reduced Triglyceride Levels

    taurine supplementation significantly decreased TG (WMD = -0.56 mg/dL, 95% CI: -0.92 to -0.2, p = 0.002, I² = 63%)

    Effect
    Beneficial
    Effect size
    Large
    Dose
    variable (studies used <3 g/day or 3 g/day)
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