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Effects of skim milk fermented with Lactobacillus plantarum WW on the constitutions of rats fed a high-fat diet.

  • 2020-06
  • Journal of Dairy Science 103(6)
    • Yang Li
    • Junrui Wu
    • Chengxu Cao
    • Xinyuan Zhu
    • Xueting Sun
    • R. Wu

Abstract

This study investigated the effects of Lactobacillus plantarum WW-fermented skim milk (FSM) on the physiques of rats fed a high-fat diet and the mechanism of lipid lowering. Sprague-Dawley rats were randomly divided into a normal diet group (A), a high-fat diet group (B), a skim milk diet group (C), and an L. plantarum WW FSM diet group (D). After 12-wk feeding, we found that treatment with L. plantarum WW FSM could significantly alleviate symptoms in the pathological group. Meanwhile, high-throughput sequencing analysis showed that L. plantarum WW FSM also had a certain regulatory effect on the intestinal microorganisms in rats, which can increase the number of lactic acid bacteria and Bacteroides in the intestine. More importantly, real-time quantitative PCR and Western blot analysis showed that the probiotic was also involved in the expression of genes related to fat metabolism, especially the PPARB and CEBPB genes. Our study supports the hypothesis that the WW strain of L. plantarum could be a potential probiotic to be used in functional foods to alter lipid metabolism and reduce cholesterol levels.

Keywords: Lactobacillus plantarum WW; high-fat diet; hyperlipidemia; lipid metabolism.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus Bulgaricus & Lactobacillus PlantarumAltered Lipid MetabolismBeneficial
Large
Lactobacillus Bulgaricus & Lactobacillus PlantarumImproved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced Symptoms Associated with High-Fat DietBeneficial
Moderate
Lactobacillus plantarumAltered Lipid MetabolismBeneficial
Large
Lactobacillus plantarumReduced Symptoms Associated with High-Fat DietBeneficial
Moderate
Lactobacillus plantarumReduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum 14DAltered Lipid MetabolismBeneficial
Large
Lactobacillus plantarum 14DReduced Pathological SymptomsBeneficial
Large
Lactobacillus plantarum 14DReduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum 14DRegulated Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum DR7Improved Lipid MetabolismBeneficial
Large
Lactobacillus plantarum DR7Increased Lactic Acid Bacteria LevelsBeneficial
Moderate
Lactobacillus plantarum DR7Reduced Pathological SymptomsBeneficial
Large
Lactobacillus plantarum DR7Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum DSM 6595Improved Fat Metabolism Gene ExpressionBeneficial
Moderate
Lactobacillus plantarum DSM 6595Improved Gut Microbiota CompositionBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced Hyperlipidemia SymptomsBeneficial
Large
Lactobacillus plantarum DSM 6595Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum DSM 6596Improved Intestinal Microbial CompositionBeneficial
Moderate
Lactobacillus plantarum DSM 6596Improved Lipid MetabolismBeneficial
Large
Lactobacillus plantarum DSM 6596Reduced Symptoms Associated with High-Fat DietBeneficial
Moderate
Lactobacillus plantarum L-137Reduced Hyperlipidemia SymptomsBeneficial
Large
Lactobacillus plantarum L-137Regulated Intestinal MicroorganismsBeneficial
Moderate
Lactobacillus plantarum LP-01Altered Lipid MetabolismBeneficial
Large
Lactobacillus plantarum LP-01Increased Beneficial Intestinal MicroorganismsBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Hyperlipidemia SymptomsBeneficial
Large
Lactobacillus plantarum LP09Altered Lipid MetabolismBeneficial
Large
Lactobacillus plantarum LP09Increased Autochthonous Lactic Acid Bacteria LevelsBeneficial
Moderate
Lactobacillus plantarum LP09Increased Bacteroides Levels in the IntestineBeneficial
Moderate
Lactobacillus plantarum LP09Reduced Hyperlipidemia SymptomsBeneficial
Large
Lactobacillus plantarum LP09Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum Lp-115Enhanced Beneficial Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum Lp-115Improved Fat Metabolism Gene ExpressionBeneficial
Moderate
Lactobacillus plantarum Lp-115Improved Lipid MetabolismBeneficial
Large
Lactobacillus plantarum Lp-115Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum N13Altered Lipid MetabolismBeneficial
Large
Lactobacillus plantarum N13Reduced Pathological SymptomsBeneficial
Large
Lactobacillus plantarum N13Regulated Intestinal MicroorganismsBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Enhanced Fat Metabolism Gene ExpressionBeneficial
Large
Lactobacillus plantarum Rosell-1012Reduced Symptoms of High-Fat Diet PathologiesBeneficial
Large
Lactobacillus plantarum Rosell-1012Regulated Intestinal MicroorganismsBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Fat Metabolism RegulationBeneficial
Large
Lactobacillus plantarum Rosell-AReduced Symptoms Associated with High-Fat DietBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum Rosell-ARegulated Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum SD5209Improved Lipid MetabolismBeneficial
Large
Lactobacillus plantarum SD5209Increased Beneficial Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Symptoms Associated with High-Fat DietBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum SD-5209Improved Beneficial Intestinal BacteriaBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced Blood Lipid LevelsBeneficial
Large
Lactobacillus plantarum SD-5209Reduced Pathological SymptomsBeneficial
Large
Lactobacillus plantarum UALp-05Enhanced Fat Metabolism Gene ExpressionBeneficial
Large
Lactobacillus plantarum UALp-05Reduced Symptoms Associated with High-Fat DietBeneficial
Moderate
Lactobacillus plantarum UALp-05MImproved Lipid MetabolismBeneficial
Large
Lactobacillus plantarum UALp-05MIncreased Beneficial Gut MicrobiotaBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced Symptoms Associated with High-Fat DietBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Symptoms Associated with High-Fat DietBeneficial
Moderate
Lactobacillus plantarum WCFS1Improved Fat Metabolism Gene ExpressionBeneficial
Moderate
Lactobacillus plantarum WCFS1Reduced Symptoms of High-Fat Diet PathologiesBeneficial
Large
Lactobacillus plantarum WCFS1Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus plantarum WCFS1Regulated Gut MicrobiotaBeneficial
Moderate

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