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Hypocholesterolemic effect of sonication-killed Bifidobacterium longum isolated from healthy adult Koreans in high cholesterol fed rats

  • 2010-09
  • Archives of Pharmacal Research 33(9)
    • H. Shin
    • Shin‐Young Park
    • Do Kyung Lee
    • S. A. Kim
    • H. An
    • Jung Rae Kim
    • M. J. Kim
    • Min Gyeong Cha
    • S. Lee
    • Kyung Joo Kim
    • K. Lee
    • N. Ha

Abstract

We have previously reported that live Bifidobacterium longum SPM1207, a strain isolated from healthy adult Koreans, significantly reduced serum cholesterol in broth and rat. We here examined the effect of oral administration of sonication-killed B. longum SPM1207 on serum cholesterol in rats in order to investigate whether this killed strain could be utilized as a potent probiotics for human and animals. Dietary treatments consisted of 3 treatment groups of 24 rats each randomly assigned to either normal diet, high cholesterol diet and saline (HCS), or high cholesterol diet and sonication-killed B. longum SPM1207 (HCKB) for 3 weeks. Although HDL-cholesterol levels in the serum were not significantly (p > 0.05) different between HCKB rats and HCS rats, total and LDL-cholesterol levels in the serum were significantly (p < 0.05) less increased in HCKB (total: 177.71 mg/dL, LDL-: 60.50 mg/dL) rats when compared to HCS (total: 237.17 mg/dL, LDL-: 71.50 mg/dL) rats. AI was significantly (p < 0.05) lower in HCKB (4.95 mg/dL) rats when compared to HCS (9.22 mg/dL) rats. Body weight increase and relative liver weight were significantly (p < 0.05) lower in HCKB rats when compared to HCS rats. Over the time, high cholesterol diet caused dry feces accompanied by decreased fecal water content (66.00 to 61.94%) but sonication-killed B. longum SPM1207 administration increased fecal water content (71.58 to 74.25%). The results in the current study provide evidence that the sonication-killed cells of B. logum SPM1207 isolated from healthy adult Koreans have a greater potential to be used as a cholesterol-lowering agent. Furthermore, the current study suggest that this killed specific strain may play role in part in blocking the body weight increase and relieving or eliminating constipation.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium longum B1-05Improved Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum B1-05Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum B1-05Reduced Body WeightBeneficial
Moderate
Bifidobacterium longum B1-05Reduced ConstipationBeneficial
Moderate
Bifidobacterium longum B1-05Reduced LDL CholesterolBeneficial
Moderate
Bifidobacterium longum B1-05Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum BI-05Increased Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum BI-05Increased Lower Body WeightBeneficial
Moderate
Bifidobacterium longum BI-05Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum BI-05Reduced LDL CholesterolBeneficial
Moderate
Bifidobacterium longum BI-05Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum BL03Improved Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum BL03Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum BL03Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum BL03Reduced ConstipationBeneficial
Moderate
Bifidobacterium longum BL03Reduced Serum Cholesterol LevelsBeneficial
Large
Bifidobacterium longum HA-135Improved Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum HA-135Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum HA-135Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum HA-135Reduced LDL CholesterolBeneficial
Moderate
Bifidobacterium longum HA-135Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum HA-135Relieved ConstipationBeneficial
Moderate
Bifidobacterium longum iVE-15Reduced ConstipationBeneficial
Moderate
Bifidobacterium longum iVE-15Reduced LDL CholesterolBeneficial
Moderate
Bifidobacterium longum iVE-15Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum KABP-042Improved Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum KABP-042Reduced Arterial StiffnessBeneficial
Large
Bifidobacterium longum KABP-042Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum KABP-042Reduced LDL Cholesterol LevelsBeneficial
Large
Bifidobacterium longum KABP-042Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum MAK34B12LIncreased Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum MAK34B12LReduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum MAK34B12LReduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum MAK34B12LReduced LDL CholesterolBeneficial
Moderate
Bifidobacterium longum MAK34B12LReduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum MM-2Increased Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum MM-2Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum MM-2Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum MM-2Reduced LDL CholesterolBeneficial
Moderate
Bifidobacterium longum MM-2Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum Rosell-175Improved Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum Rosell-175Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum Rosell-175Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum Rosell-175Reduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum Rosell-175 MEReduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum Rosell-175 MEReduced Body WeightBeneficial
Moderate
Bifidobacterium longum Rosell-175 MEReduced Cholesterol LevelsBeneficial
Large
Bifidobacterium longum Rosell-175 MERelieved ConstipationBeneficial
Moderate
Bifidobacterium longum SD-5588Increased Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum SD-5588Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum SD-5588Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum SD-5588Reduced ConstipationBeneficial
Moderate
Bifidobacterium longum SD-5588Reduced LDL CholesterolBeneficial
Moderate
Bifidobacterium longum SD-5588Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum SP54Increased Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum SP54Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum SP54Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Improved Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum subsp. longum UABI-14Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Reduced ConstipationBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Reduced Serum Cholesterol LevelsBeneficial
Large
Bifidobacterium longum UABI-14Increased Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum UABI-14Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum UABI-14Reduced Body Weight GainBeneficial
Moderate
Bifidobacterium longum UABI-14Reduced LDL CholesterolBeneficial
Moderate
Bifidobacterium longum UABl-14Improved Fecal Water ContentBeneficial
Moderate
Bifidobacterium longum UABl-14Reduced Atherogenic IndexBeneficial
Large
Bifidobacterium longum UABl-14Reduced Body WeightBeneficial
Moderate

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