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Abstract

A recent animal study demonstrated that administration of Lactobacillus plantarum HAC01 isolated from Korean kimchi improved glycemic control in type 2 diabetic mice. In the present study, we evaluated Lactobacillus plantarum HAC01's effects on metabolic parameters of prediabetic human subjects. Forty subjects with isolated impaired glucose tolerance were randomly assigned to receive a daily placebo (n = 20) or a dose of Lactobacillus plantarum HAC01 (n = 20) over eight weeks. The primary endpoint was a change in 2 h postprandial glucose (2h-PPG) levels and the secondary endpoints were assessment of other glucose metabolism parameters, including HbA1c, gut microbiota composition, and fecal short-chain fatty acids (SCFAs). The group with a diet supplemented with Lactobacillus plantarum HAC01 saw a significant reduction in 2h-PPG and HbA1c levels compared to the placebo group. Fasting plasma glucose, insulin, HOMA-IR, QUICKI, microbiota composition, and fecal SCFAs, however, were not significantly altered. No serious adverse effects were reported. This is the first clinical trial to show a beneficial effect of single-strain probiotic supplementation administered over eight weeks on HbA1c levels in prediabetic subjects.

Keywords: 2h-PPG; HbA1c; Lactobacillus plantarum; clinical trial; prediabetes.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus Bulgaricus & Lactobacillus PlantarumImproved Glycemic ControlBeneficial
Large
Lactobacillus Bulgaricus & Lactobacillus PlantarumIncreased Blood Glucose LevelsNeutral
Small
Lactobacillus Bulgaricus & Lactobacillus PlantarumNo Significant Adverse EventsNeutral
Small
Lactobacillus Bulgaricus & Lactobacillus PlantarumUnchanged Insulin SensitivityNeutral
Small
Lactobacillus plantarumImproved Glycemic ControlBeneficial
Large
Lactobacillus plantarum 14DReduced Blood HbA1c LevelsBeneficial
Moderate
Lactobacillus plantarum 14DReduced Postprandial Glucose LevelsBeneficial
Moderate
Lactobacillus plantarum DR7Reduced Blood HbA1c LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6595Improved Hemoglobin A1c LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6595Improved Postprandial Glucose LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Improved Glycemic ControlBeneficial
Large
Lactobacillus plantarum DSM 6596Maintained Gut Microbiota StabilityNeutral
Small
Lactobacillus plantarum HA-119Reduced Blood HbA1c LevelsBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced Postprandial Glucose LevelsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved Glycemic ControlBeneficial
Large
Lactobacillus plantarum KABP™-061Increased Blood Glucose LevelsNeutral
Small
Lactobacillus plantarum Rosell-1012Reduced Blood HbA1c LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Reduced Postprandial Glucose LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Glycemic ControlBeneficial
Large
Lactobacillus plantarum Rosell-AStable Fasting Plasma GlucoseNeutral
Small
Lactobacillus plantarum SD-5209Reduced Blood HbA1c LevelsBeneficial
Moderate
Lactobacillus plantarum UALp-05MImproved Glycemic ControlBeneficial
Large
Lactobacillus plantarum VPro 10Improved Glycemic ControlBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Blood HbA1c LevelsBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Postprandial Glucose LevelsBeneficial
Moderate
Lactobacillus plantarum WCFS1Improved Glycemic ControlBeneficial
Large
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