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Orange Juice and Yogurt Carrying Probiotic Bacillus coagulans GBI-30 6086: Impact of Intake on Wistar Male Rats Health Parameters and Gut Bacterial Diversity

  • 2021-04-01
  • Frontiers in Microbiology 12
    • Carine N. Almada-Érix
    • C. N. Almada
    • Lucélia Cabral
    • Viviane Priscila Barros de Medeiros
    • A. R. Roquetto
    • V. A. Santos-Junior
    • M. Fontes
    • A. E. S. S. Gonçalves
    • Andrey Dos Santos
    • P. Lollo
    • M. Magnani
    • A. Sant’Ana

Abstract

This study aimed to investigate the impact of the food matrix (orange juice and yogurt) on the effects of the spore-forming probiotic microorganism Bacillus coagulans GBI-30 6086 in health parameters and gastrointestinal tract (gut) bacterial diversity in Wistar male rats. Rats (n = 48) were randomly distributed into six groups. The groups were the Control (which received sterile distilled water), Juice (which received orange juice), Yogurt (which received yogurt), Probiotic Bacillus (which received B. coagulans GBI-30 6086 in distilled water), Probiotic Juice (which received orange juice with B. coagulans GBI-30 6086), and Probiotic Yogurt (which received yogurt with B. coagulans GBI-30 6086). Each animal belonging to the different groups was treated for 21 days. The daily administration of probiotic juice or probiotic yogurt did not affect the rats' food or body weight. Rats fed with Probiotic Yogurt showed lower glucose and triglycerides levels (p < 0.05) in comparison to the control group (p < 0.05), while no changes in these parameters were observed in the rats fed with Probiotic Juice. Rats fed with Probiotic Yogurt showed a higher gut bacterial diversity than the control group (p < 0.05), and higher abundance (p < 0.05) of Vibrionales, Enterobacteriales, Burkholderiales, Erysipelotrichales, and Bifidobacteriales compared to all other groups. No changes were observed in the expression levels of antioxidant enzymes or heat shock protein 70 of rats fed with probiotic yogurt or probiotic juice. Results reveal that the consumption of yogurt containing B. coagulans GBI-30 6086 decreases triglycerides and glucose levels and positively impacts the gut bacterial ecology in healthy rats. These animal model findings indicate that the matrix also impacts the functionality of foods carrying spore-forming probiotics. Besides, this research indicates that yogurt is also a suitable food carrier of Bacillus coagulans GBI-30 6086.

Keywords: beneficial microbes; fermented food; functional food; intestinal microbiome; spore-forming bacteria.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus coagulansImproved Gut Bacterial DiversityBeneficial
Moderate
Bacillus coagulansIncreased Abundance of Gut BacteriaBeneficial
Large
Bacillus coagulansReduced Serum Glucose LevelsBeneficial
Moderate
Bacillus coagulansReduced Triglyceride LevelsBeneficial
Moderate
Bacillus coagulans GBI-30, 6086Improved Blood Glucose LevelsBeneficial
Moderate
Bacillus coagulans GBI-30, 6086Improved Gut Bacterial DiversityBeneficial
Moderate
Bacillus coagulans GBI-30, 6086Increased Abundance of Gut BacteriaBeneficial
Large
Bacillus coagulans GBI-30, 6086Reduced Triglyceride LevelsBeneficial
Moderate
Bacillus coagulans ProDuraImproved Gut Bacterial DiversityBeneficial
Moderate
Bacillus coagulans ProDuraLower Plasma Glucose LevelsBeneficial
Moderate
Bacillus coagulans ProDuraReduced Triglyceride LevelsBeneficial
Moderate
Bacillus coagulans SC208Improved Gut Bacterial DiversityBeneficial
Moderate
Bacillus coagulans SC208Increased Abundance of Gut BacteriaBeneficial
Large
Bacillus coagulans SC208Reduced Serum Glucose LevelsBeneficial
Moderate
Bacillus coagulans SC208Reduced Triglyceride LevelsBeneficial
Moderate
Bacillus coagulans SNZ-1969Improved Gut Bacterial DiversityBeneficial
Moderate
Bacillus coagulans SNZ-1969Increased Abundance of Specific Bacterial SpeciesBeneficial
Large
Bacillus coagulans SNZ-1969Lower Plasma Glucose LevelsBeneficial
Moderate
Bacillus coagulans SNZ-1969Reduced Triglyceride LevelsBeneficial
Moderate
Bacillus coagulans Unique IS-2Improved Gut Bacterial DiversityBeneficial
Moderate
Bacillus coagulans Unique IS-2Increased Abundance of Gut BacteriaBeneficial
Large
Bacillus coagulans Unique IS-2Lower Plasma Glucose LevelsBeneficial
Moderate
Bacillus coagulans Unique IS-2Reduced Triglyceride LevelsBeneficial
Moderate
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