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"Physicochemical, immunomodulatory and safety aspects of milks fermented with Lactobacillus paracasei isolated from kefir".

  • 2019-09
  • Food Research International 123
    • A. Bengoa
    • Carolina Iraporda
    • L. Acurcio
    • S. H. de Cicco Sandes
    • Karen Costa
    • Gabriele Moreira Guimarães
    • R. M. Esteves Arantes
    • E. Neumann
    • Á. Cantini Nunes
    • J. R. Nicoli
    • G. L. Garrote
    • A. Abraham

Abstract

The use of Lactobacillus paracasei strains isolated from kefir grains as starters for the development of functional dairy products was evaluated. The physicochemical and immunomodulatory properties of milks fermented with L. paracasei CIDCA8339, CIDCA83123 and CIDCA83124 were analyzed. The three strains produced bioactive metabolites during fermentation, since the fermented milk supernatants were able to downregulate >75% of the induced innate immune response in vitro. Although all strains presented absence of hemolytic activity and susceptibility to antibiotics, L. paracasei CIDCA8339 presented more attractive probiotic and technological properties. Mice consuming the fermented milk with L. paracasei CIDCA 8339 did not present significant modifications in sIgA levels or TNF-α, TGF-β and IL-10 mRNA expression in ileum. Additionally, a decrease of INF-γ level in ileum and no microbiological translocation to liver and spleen was observed. These results demonstrate that L. paracasei CIDCA8339 represents a safe promising potential probiotic strain for the development of functional foods.

Keywords: Exopolysaccharide; Functional foods; Kefir; Lactobacillus paracasei; Safety.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus kefirReduced Innate Immune ResponseBeneficial
Large
Lactobacillus paracasei LPC09Absence of Hemolytic ActivityNeutral
Large
Lactobacillus paracasei LPC09Increased Antibiotic SusceptibilityNeutral
Large
Lactobacillus paracasei LPC09Reduced IFN-γ LevelsBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Induced Innate Immune ResponseBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALs-04Reduced IFN-γ LevelsBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Reduced Innate Immune ResponseBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALs-04Safe for Consumption with No Adverse Immune EffectsBeneficial
Moderate
Lactobacillus paracasei VPro 224Improved Probiotic Functionality for Functional Foods DevelopmentBeneficial
Large
Lactobacillus paracasei VPro 224Reduced Induced Innate Immune ResponseBeneficial
Large
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