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Abstract

Lactobacillus species have been shown to enhance intestinal epithelial barrier function, modulate host immune responses, and suppress the growth of pathogenic bacteria, yeasts, molds, and viruses. Thus, lactobacilli have been used as probiotics for treating various diseases, including intestinal disorders, and as biological preservatives in the food and agricultural industries. However, the molecular mechanisms used by lactobacilli to suppress pathogenic bacterial infections have been poorly characterized. We previously isolated Lactobacillus plantarum JSA22 from buckwheat sokseongjang, a traditional Korean fermented soybean food, which possessed high enzymatic, fibrinolytic, and broad-spectrum antimicrobial activity against foodborne pathogens. In this study, we investigated the effects of L. plantarum JSA22 on the growth of S. Typhimurium and S. Typhimurium-induced cytotoxicity by stimulating the host immune response in intestinal epithelial cells. The results showed that coincubation of S. Typhimurium and L. plantarum JSA22 with intestinal epithelial cells suppressed S. Typhimurium infection, S. Typhimurium-induced NF-kappaB activation, and IL-8 production, and lowered the phosphorylation of both Akt and p38. These data indicated that L. plantarum JSA22 has probiotic properties, and can inhibit S. Typhimurium infection of intestinal epithelial cells. Our findings can be used to develop therapeutic and prophylactic agents against pathogenic bacteria.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced IL-8 ProductionBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced Nuclear Factor Kappa B ActivationBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced Pathogen GrowthBeneficial
Large
Lactobacillus plantarumReduced IL-8 ProductionBeneficial
Moderate
Lactobacillus plantarumReduced NF-kappaB Activation due to S. TyphimuriumBeneficial
Moderate
Lactobacillus plantarumReduced S. Typhimurium InfectionBeneficial
Large
Lactobacillus plantarum HA-119Reduced IL-8 ProductionBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced Nuclear Factor Kappa B ActivationBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced S. Typhimurium InfectionBeneficial
Large
Lactobacillus plantarum KABP™-061Reduced IL-8 ProductionBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Nuclear Factor Kappa B ActivationBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced S. Typhimurium InfectionBeneficial
Large
Lactobacillus plantarum N13Reduced IL-8 ProductionBeneficial
Moderate
Lactobacillus plantarum N13Reduced NF-kappaB Activation due to S. TyphimuriumBeneficial
Moderate
Lactobacillus plantarum N13Reduced S. Typhimurium InfectionBeneficial
Large
Lactobacillus plantarum SD-5209Reduced IL-8 ProductionBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced Nuclear Factor Kappa B ActivationBeneficial
Moderate
Lactobacillus plantarum SD-5209Suppressed Salmonella Typhimurium InfectionBeneficial
Large
Lactobacillus plantarum SD5209Reduced Bacterial Infection SeverityBeneficial
Large
Lactobacillus plantarum SD5209Reduced Inflammatory ResponseBeneficial
Large
Lactobacillus plantarum SD5209Reduced Pathogen GrowthBeneficial
Large
Lactobacillus plantarum UALp-05MReduced CytotoxicityBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced Infection RateBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced Inflammation LevelsBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Akt PhosphorylationBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced IL-8 ProductionBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Nuclear Factor Kappa B ActivationBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Phosphorylation of p38Beneficial
Moderate
Lactobacillus plantarum VPro 10Suppressed Salmonella Typhimurium InfectionBeneficial
Large
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