Qualification of tropical fruit-derived Lactobacillus plantarum strains as potential probiotics acting on blood glucose and total cholesterol levels in Wistar rats.
- 2019-10
- Food Research International 124
- W. K. A. da Costa
- Larissa Ramalho Brandão
- M. E. Martino
- Estefânia F Garcia
- A. F. Alves
- E. L. de Souza
- Jailane de Souza Aquino
- M. Saarela
- F. Leulier
- H. Vidal
- M. Magnani
- PubMed: 31466629
- DOI: 10.1016/J.FOODRES.2018.08.035
Abstract
Tropical fruit and their industrial processing byproducts have been considered sources of probiotic Lactobacillus. Sixteen tropical fruit-derived Lactobacillus strains were assessed for growth-promoting effects using a host-commensal nutrient scarcity model with Drosophila melanogaster (Dm). Two Lactobacillus strains (L. plantarum 49 and L. plantarum 201) presenting the most significant effects (p ≤ .005) on Dm growth were selected and evaluated for their safety and beneficial effects in adult male Wistar rats during 28 days of administration of 9 log CFU/day, followed by 14 days of wash-out. Daily administration of L. plantarum 49 and L. plantarum 201 did not affect (p > .05) food intake or morphometric parameters. Both strains were associated with reduction (p ≤ .05) in blood glucose levels after 28 days of administration and after wash-out period; glucose levels remained reduced only in the group that received L. plantarum 49. Both strains were able to reduce (p ≤ .05) total cholesterol levels after 14 days of administration; after the wash-out period these levels remained reduced only in the group that received L. plantarum 201. L. plantarum 49 and L. plantarum 201 were detected in the intestine and did not cause alteration or translocate to spleen, kidneys or liver during the experimental or wash-out period. These results indicate that L. plantarum 49 and L. plantarum 201 present potential for use as probiotics with intrinsic abilities to modulate biochemical parameters of interest for the management of metabolic diseases.
Keywords: Grow promotion; Lactobacillus plantarum; Metabolic modulation; Probiotics; Safety.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Safety of Consumption | Neutral | Large |
| Lactobacillus plantarum | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum | No Adverse Effect on Food Intake or Body Measurements | Neutral | Moderate |
| Lactobacillus plantarum | No Metastasis to Other Organs | Neutral | Large |
| Lactobacillus plantarum | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum DR7 | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum DR7 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Absence of Bacterial Translocation to Liver or Spleen | Neutral | Moderate |
| Lactobacillus plantarum DSM 6595 | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Unchanged Food Intake | Neutral | Small |
| Lactobacillus plantarum KABP™-061 | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum KABP™-061 | No Adverse Effects in Rats | Neutral | Large |
| Lactobacillus plantarum KABP™-061 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | No Adverse Morphometric Parameter Effects | Neutral | Moderate |
| Lactobacillus plantarum Rosell-1012 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | No Adverse Effects on Food Intake | Neutral | Small |
| Lactobacillus plantarum Rosell-A | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Increased Intestinal Retention Safety | Neutral | Moderate |
| Lactobacillus plantarum SD-5209 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05 | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05 | Increased Safety of Probiotic Use | Neutral | Moderate |
| Lactobacillus plantarum UALp-05 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | No Adverse Effects on Body Weight or Food Intake | Neutral | Large |
| Lactobacillus plantarum UALp-05M | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced Total Cholesterol Levels | Beneficial | Moderate |