Skip to main content

Saccharomyces cerevisiae fungemia: Risk factors, outcome and links with S. boulardii-containing probiotic administration.

  • 2021-05
  • Infectious Diseases Now 51(3)
    • A. Poncelet
    • L. Ruelle
    • D. Konopnicki
    • V. Y. Miendje Deyi
    • N. Dauby


Saccharomyces cerevisiae fungemia: risk factors, outcome and links with S. boulardii-containing probiotic administration.

Objective: The aim of our study was to review cases of S. cerevisiae fungemia along with the corresponding risk factors (including S. boulardii probiotic intake), treatment and outcomes.

Patients and methods: Retrospective study (2005-2017) of S. cerevisiae fungemia. All the data were extracted from medical files.

Results: We identified 10 patients with S. cerevisiae fungemia. Mean age was 59.4 years (range 21-88). Four fifths (80%) were on total parenteral or enteral nutrition, 70% had a central venous line, and 30% were admitted in an Intensive Care Unit (ICU). S. boulardii-containing probiotic prescription was identified in 6 subjects. Three patients with no risk factors such as ICU or central venous catheter were 80 years old or more. Mortality rate was 50%.

Conclusion: S. cerevisiae fungemia is a rare but life-threatening infection, associated with intake of probiotics containing S. boulardii. Besides classical risk factors, older age should be a contraindication for these probiotics.

Keywords: Fungemia; Probiotics; Saccharomyces boulardii.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Saccharomyces boulardiiSaccharomyces Cerevisiae FungemiaHarmful
Saccharomyces cerevisiaeIncreased Mortality RateHarmful
Saccharomyces cerevisiaeSaccharomyces Cerevisiae FungemiaHarmful
⬆ Back to top
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.
Receive updates about our products, services, sales, and special offers. Unsubscribe anytime. See our Privacy Policy for details on how we handle your information.

Join Our Community

Use to get in touch.