The efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials.

2013-02-08
Journal of dietary supplements 10(1)
- Igho Onakpoya
- Lucy Davies
- Paul Posadzki
- Edzard Ernst

PubMed: 23419021
DOI: 10.3109/19390211.2012.760508

Study Design

Type: Systematic Review
Population: obese and overweight individuals
Methods: Systematic review of RCTs on Irvingia gabonensis for body weight reduction

The aim of this systematic review was to evaluate the evidence from randomized controlled trials (RCTs) involving the use of the African Bush Mango, Irvingia gabonensis for body weight reduction in obese and overweight individuals. Electronic and nonelectronic searches were conducted to identify relevant RCTs. The bibliographies of located articles were also searched. No age, gender, or language restrictions were imposed. The reporting quality of identified RCTs was assessed using a methodological checklist adapted from the Consolidated Standard of Reporting Trials Statement and Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Two reviewers independently determined eligibility and assessed the reporting quality of included studies. Three RCTs were identified, and all were included. The RCTs all had flaws in the reporting of their methodology. All RCTs reported statistically significant reductions in body weight and waist circumference favoring I. gabonensis over placebo. The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile. Adverse events included headache and sleep difficulty. Due to the paucity and poor reporting quality of the RCTs, the effect of I. gabonensis on body weight and related parameters are unproven. Therefore, I. gabonensis cannot be recommended as a weight loss aid. Future research in this area should be more rigorous and better reported.

Research Insights

African Mango→Improved Blood Lipid Profile
The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile.
Effect
Beneficial
Effect size
Small
African Mango→Increased High-Density Lipoprotein Cholesterol
The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile.
Effect
Beneficial
Effect size
Small
African Mango→Reduced Body Weight
All RCTs reported statistically significant reductions in body weight ... favoring I. gabonensis over placebo.
Effect
Beneficial
Effect size
Small
African Mango→Reduced LDL Cholesterol
The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile.
Effect
Beneficial
Effect size
Small
African Mango→Reduced Total Cholesterol
The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile.
Effect
Beneficial
Effect size
Small
African Mango→Reduced Triglyceride Levels
The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile.
Effect
Beneficial
Effect size
Small
African Mango→Reduced Waist Circumference
All RCTs reported statistically significant reductions in ... waist circumference favoring I. gabonensis over placebo.
Effect
Beneficial
Effect size
Small

Adverse Events Reported

African Mango→headache
Adverse events included headache and sleep difficulty.
Finding
Reported
African Mango→sleep difficulty
Adverse events included headache and sleep difficulty.
Finding
Reported