Across 3 studies, 2 reported beneficial small effects on reducing triglyceride levels, while one meta-analysis found a neutral non-significant effect. The only reported dose was 150 mg twice daily, with effects observed in a 90-day trial. Evidence is drawn from clinical populations, including adults with metabolic syndrome and overweight/obese individuals.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One meta-analysis found a neutral non-significant effect, indicating inconsistency, and the positive findings come from a small RCT (n=24) and systematic reviews, limiting confidence. Further high-quality trials are needed.
The reported adverse events were minor in these 5 RCTs.
from: The Effects of Irvingia gabonensis Seed Extract Supplementation on Anthropometric and CardAdverse events included headache and sleep difficulty.
from: The efficacy of Irvingia gabonensis supplementation in the management of overweight and obAdverse events included headache and sleep difficulty.
from: The efficacy of Irvingia gabonensis supplementation in the management of overweight and obdecreasing triglyceride levels (net percent change = -29%; 95% CI: -76%, 19%).
triglycerides (2.5±1.2 vs. 2.0±1.1 mmol/L, P<.05)
The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile.