Across 3 studies, 2 reported small beneficial effects of African mango (Irvingia gabonensis) supplementation on reducing triglyceride levels, while 1 meta-analysis found a neutral effect that did not reach statistical significance. The only available study with a specific dose used 150 mg twice daily for 90 days in a clinical population with metabolic syndrome. Effects were predominantly small in magnitude, and the median study duration was 90 days, suggesting effects may be observed after several weeks of supplementation.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The meta-analysis (highest evidence score) found a neutral effect with a wide confidence interval crossing zero, indicating uncertainty. One of the two beneficial studies was a systematic review that may include overlapping data from the meta-analysis. Dosing data are limited to a single small RCT (n=24).
The reported adverse events were minor in these 5 RCTs.
from: The Effects of Irvingia gabonensis Seed Extract Supplementation on Anthropometric and CardAdverse events included headache and sleep difficulty.
from: The efficacy of Irvingia gabonensis supplementation in the management of overweight and obAdverse events included headache and sleep difficulty.
from: The efficacy of Irvingia gabonensis supplementation in the management of overweight and obdecreasing triglyceride levels (net percent change = -29%; 95% CI: -76%, 19%).
triglycerides (2.5±1.2 vs. 2.0±1.1 mmol/L, P<.05)
The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile.