Across 3 studies, 3 reported small beneficial effects of African mango (Irvingia gabonensis) supplementation on reducing triglyceride levels, with 2 of these reaching statistical significance. Evidence comes primarily from a meta-analysis, an RCT (150 mg twice daily for 90 days), and a systematic review, all in clinical populations (metabolic syndrome, overweight/obese adults). Effects are typically observed at 90 days.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The only study reporting a specific dose used 150 mg twice daily, but overall dose reporting is limited.
The reported adverse events were minor in these 5 RCTs.
from: The Effects of Irvingia gabonensis Seed Extract Supplementation on Anthropometric and CardAdverse events included headache and sleep difficulty.
from: The efficacy of Irvingia gabonensis supplementation in the management of overweight and obAdverse events included headache and sleep difficulty.
from: The efficacy of Irvingia gabonensis supplementation in the management of overweight and obdecreasing triglyceride levels (net percent change = -29%; 95% CI: -76%, 19%).
triglycerides (2.5±1.2 vs. 2.0±1.1 mmol/L, P<.05)
The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile.