What Is the Involvement of Gut Microbiome in the Pathophysiology of Diabetes?
- 2025-10-16
- Biomolecules 15(10)
- Kajetan Kiełbowski
- Paulina Plewa
- Jan Zadworny
- Patrycja Stodolak
- Anna Jędrasiak
- Estera Bakinowska
- Andrzej Pawlik
- PubMed: 41154691
- DOI: 10.3390/biom15101463
Study Design
- Type
- Review
- Methods
- In this review, we discuss recent findings on the intricate relationship between the gut microbiome and DM, including its complications.
Diabetes mellitus (DM) encompasses a group of metabolic diseases characterised by abnormal glucose levels. The pathophysiology of DM involves intricate disruptions in glucose metabolism and immune regulation. The gut microbiome is known to play a crucial role in human health and disease, and changes in its composition have been reported in numerous conditions, including DM. In this review, we discuss recent findings on the intricate relationship between the gut microbiome and DM, including its complications. We highlight the involvement of gut microorganisms in inflammation and metabolic processes, and we summarise current evidence on how antidiabetic therapies influence microbiome composition and activity. Finally, we explore the potential role of microbiome monitoring in predicting treatment response.
Research Insights
The study observed that consumption of Lactobacillus gasseri BNR17 was associated with improvements in blood glucose-related outcomes in subjects with diabetes.
- Effect
- Beneficial
- Effect size
- Moderate
Lactobacillus gasseri BNR17 consumption was reported to have a favorable effect on body weight-related measures.
- Effect
- Beneficial
- Effect size
- Small