Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Depression Symptoms

Safety in these studies

Overall tolerabilityReported
Randomized controlled trial (RCT) findings reveal that while interventions like saffron and vitamin D show promise, significant limitations persist, including inconsistent efficacy, limited long-term safety data, and potential interactions with perinatal physiology.
from: Supplementary approaches to perinatal depression: a review of pathogenesis, herbal interve

2 of 2 papersPopulation:

A Recipe for Resilience: A Systematic Review of Diet and Adolescent Mental Health.
- 2025-11-24
- Systematic Review
- Nutrients 17(23)
- - Jade E Tucker
  - Anthony M Brennan
  - David Benton
  - Hayley A Young
- PubMed: 41373968
- DOI: 10.3390/nu17233677
6 Insights on
- Reduced Depression Symptoms
- High evidence
- Rigorous Journal
- Children
Examined exposures included vitamin D, omega-3s, polyphenol-rich foods, Mediterranean-style diets, and overall diet quality. Depressive symptoms were the most studied outcome... the current evidence is constrained by wide variation in assessments, small samples, and significant methodological limitations.
Effect
Neutral
Effect size
Small
Significant
No
Supplementary approaches to perinatal depression: a review of pathogenesis, herbal interventions, and dietary supplements.
- 2025-05-21
- Review
- Frontiers in psychology 16
- - Quancheng Yang
  - Yi Lv
  - Shenrong Gao
  - Yu Zhang
  - Xuejia Zhai
- PubMed: 40491948
- DOI: 10.3389/fpsyg.2025.1529339
2 Insights on
- Reduced Depression Symptoms
- Low evidence
RCT findings reveal that while interventions like saffron and vitamin D show promise
Effect
Beneficial
Effect size
Small
Significant
Yes