Across 3 studies, all 3 reported beneficial effects of Vitamin E on pain reduction, with effect sizes ranging from small to moderate. The predominant effect was moderate in one higher-quality systematic review and small in two other studies. Evidence is limited to small trials and reviews, with median study duration of 60 days (one study) and doses varying (600 mg twice daily reported in one RCT).
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). One study combined Vitamin E with other nutrients (e.g., Vitamin C), so the independent effect of Vitamin E is uncertain.
No major side effects were noticed.
from: Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylseSupplementation with ... a combination of vitamin C and E significantly improved measures of pain
as well as BCTQ symptoms subscale, and the pain.
NBF gel may provide clinical benefits as an adjunct to non-surgical periodontal therapy, with reported improvements in pain-related outcomes