Across 3 studies, all reported beneficial effects of vitamin E supplementation on pain reduction, with effect sizes ranging from small to moderate (predominantly small). The median study duration was 60 days. The evidence is limited to diverse clinical populations including fibromyalgia, carpal tunnel syndrome, and oral mucosal diseases, often in combination with other nutrients, making it difficult to isolate the specific effect of vitamin E alone.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies used vitamin E in combination with other supplements, limiting the ability to attribute effects solely to vitamin E.
No major side effects were noticed.
from: Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylseSupplementation with ... a combination of vitamin C and E significantly improved measures of pain
as well as BCTQ symptoms subscale, and the pain.
NBF gel may provide clinical benefits as an adjunct to non-surgical periodontal therapy, with reported improvements in pain-related outcomes