Bitter Orange and Reduced Pain

• Effect of Citrus Aurantium L. on pain and blood pressure in patients undergoing hand reconstructive surgery.

  • 2025-07-06
  • RCT · n = 76
  • Pain management 15(8)
  • • Farideh Askari
    • Farzaneh Ghaffari
    • Nasrin Alaee
    • Mohsen Naseri
    • Akram Tayanloo-Beik

  • PubMed: 40619705
  • DOI: 10.1080/17581869.2025.2515814

  3 Insights on

  • Reduced Pain

  • High evidence
  • Clinical

  The intervention group showed significantly greater pain reduction than the control group (p = 0.001), with CA increasing the likelihood of pain reduction by 1.73 times (Exp(B) = 1.73).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  essential oil (not specified further)