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Evidence-Based Supplement Research
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Cordyceps

Safety profile

3 studies reporting safety data

Across 3 clinical studies, no specific adverse events were significantly increased with cordyceps compared to control. Two studies reported no significant difference in gastrointestinal adverse reactions (RR: 0.80, 95%CI: 0.47-1.37) or liver and renal damage (RR: 0.32, 95%CI: 0.09-1.10). General tolerability was described as favorable in two additional analyses, with adverse reactions occurring less frequently in the cordyceps group than in the control group in one study.

Caveats: The evidence base is limited (3 studies) and studies may have been powered for efficacy rather than safety, meaning rare adverse events may not be detected. Most trials were short-term and used specific formulations; long-term safety and effects in special populations (e.g., pregnant women, children) are not established.

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