Red Grape and Reduced Systolic Blood Pressure

• Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.

  • 2025-05
  • RCT
  • Clinical physiology and functional imaging 45(3)
  • • Albert Lira
    • William Boyer
    • Trevor Gillum
    • Sean Sullivan
    • Jong-Kyung Kim

  • PubMed: 40341867
  • DOI: 10.1111/cpf.70010

  8 Insights on

  • Reduced Systolic Blood Pressure

  • High evidence

  There were no differences on the SBP … between placebo and GSE treatments

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

• The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.

  • 2024-05-16
  • RCT · n = 25
  • BMC complementary medicine and therapies 24(1)
  • • Parisa Ghanbari
    • Davoud Raiesi
    • Roghayeh Alboebadi
    • Ahmad Zarejavid
    • Mostafa Dianati
    • Hamidreza Razmi
    • Hadi Bazyar

  • PubMed: 38755622
  • DOI: 10.1186/s12906-024-04477-3

  18 Insights on

  • Reduced Systolic Blood Pressure

  • High evidence
  • Clinical

  insulin, HOMA-IR, TC, TG, LDL-c, ALT, AST, AST/ALT, SBP, DBP and MAP decreased and QUICKi and HDL-c increased significantly (p-value for all < 0.05)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  520 mg/day