Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males.

2020-10-31
Journal of nutritional science and vitaminology 66(5)
- Katherine N Dillon
- Brian Shariffi
- Brittany Thompson
- Richard Steele
- Jong-Kyung Kim

PubMed: 33132345
DOI: 10.3177/jnsv.66.427

Study Design

Type: Randomized Controlled Trial (RCT)
Population: 20 men (obese=10; normal body weight (NBW)=10)
Methods: Acute supplementation with grape seed extract (GSE) or placebo, 2 h after ingestion on different days, 1 wk apart
Blinding: Double-blind
Duration: 2 h
Funding: Unclear

Recently, it has been reported that dietary supplementation with grape seed extract (GSE) ameliorates endothelial function and increase nitric oxide (NO) bioavailability. Thus, we investigated if elevated blood pressure and aortic stiffness (AoS) characterized in obese individuals are attenuated following acute GSE supplementation. Twenty men (obese=10; normal body weight (NBW)=10) participated in this study. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR), and AoS were compared 2 h after ingestion of GSE or placebo (PL) on different days, 1 wk apart. Compared with the PL, GSE supplementation significantly decreased SBP (NBW: 103±4 vs. 99±3 mmHg; obese: 118±3 vs. 112±5 mmHg) and MAP (NBW: 75±2 vs. 72±2 mmHg; obese: 86±3 vs. 84±3 mmHg) in both groups, while there were no differences in HR, SV, DBP, TPR, and AoS. GSE supplementation significantly decreased CO in only obese group. In NBW group, TPR tended to be decreased, but there was no significant difference. Our study suggests that acute supplementation with GSE reduced both SBP and MAP via a reduction in CO in obese individuals and decreased peripheral vasoconstriction in NBW group.

Research Insights

Red Grape→Reduced Aortic Stiffness
while there were no differences in HR, SV, DBP, TPR, and AoS.
Effect
Neutral
Effect size
Small
Red Grape→Reduced Cardiac Output
GSE supplementation significantly decreased CO in only obese group.
Effect
Beneficial
Effect size
Small
Red Grape→Reduced Diastolic Blood Pressure
while there were no differences in HR, SV, DBP, TPR, and AoS.
Effect
Neutral
Effect size
Small
Red Grape→Reduced Heart Rate
while there were no differences in HR, SV, DBP, TPR, and AoS.
Effect
Neutral
Effect size
Small
Red Grape→Reduced Mean Arterial Pressure
and MAP (NBW: 75±2 vs. 72±2 mmHg; obese: 86±3 vs. 84±3 mmHg)
Effect
Beneficial
Effect size
Small
Red Grape→Reduced Stroke Volume
while there were no differences in HR, SV, DBP, TPR, and AoS.
Effect
Neutral
Effect size
Small
Red Grape→Reduced Systolic Blood Pressure
Compared with the PL, GSE supplementation significantly decreased SBP (NBW: 103±4 vs. 99±3 mmHg; obese: 118±3 vs. 112±5 mmHg)
Effect
Beneficial
Effect size
Moderate
Red Grape→Reduced Total Peripheral Resistance
In NBW group, TPR tended to be decreased, but there was no significant difference.
Effect
Neutral
Effect size
Small