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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Red Grape and Reduced Diastolic Blood Pressure

Doses used in studies

mg/day: 520 (median 520, IQR 520–520) — 1 study

Time to effect

Median: 4.8 weeks · IQR 2.9 weeks–6.7 weeks · Range 7 days–8.6 weeks — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.
- 2025-05
- RCT
- Clinical physiology and functional imaging 45(3)
- - Albert Lira
  - William Boyer
  - Trevor Gillum
  - Sean Sullivan
  - Jong-Kyung Kim
- PubMed: 40341867
- DOI: 10.1111/cpf.70010
8 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
GSE decreased resting DBP (75 ± 2 vs. 71 ± 3) compared to the placebo (DBP:71 ± 3 vs. 74 ± 3)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
- 2024-05-16
- RCT · n = 25
- BMC complementary medicine and therapies 24(1)
- - Parisa Ghanbari
  - Davoud Raiesi
  - Roghayeh Alboebadi
  - Ahmad Zarejavid
  - Mostafa Dianati
  - Hamidreza Razmi
  - Hadi Bazyar
- PubMed: 38755622
- DOI: 10.1186/s12906-024-04477-3
18 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
- Clinical
insulin, HOMA-IR, TC, TG, LDL-c, ALT, AST, AST/ALT, SBP, DBP and MAP decreased and QUICKi and HDL-c increased significantly (p-value for all < 0.05)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
520 mg/day