Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men.

2018-05
Journal of medicinal food 21(5)
- Jong-Kyung Kim
- Kyung-Ae Kim
- Hyun-Min Choi
- Seung-Kook Park
- Charles L Stebbins

PubMed: 29683391
DOI: 10.1089/jmf.2017.0133

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 9
Population: prehypertensive males (N = 9)
Methods: Effects of placebo and GSE (300 mg) on systolic blood pressure, diastolic blood pressure, mean arterial pressure, cardiac output, stroke volume, total vascular conductance, and rate × pressure product in response to two submaximal cycling workloads were compared 2 h after ingestion of GSE or placebo on different days, 1 week apart
Blinding: Double-blind
Duration: 2 h after ingestion; 1 week apart
Funding: Unclear

We tested the hypothesis that exaggerated pressor responses observed in prehypertensive males (N = 9) during dynamic exercise are attenuated following acute dietary supplementation with grape seed extract (GSE) (i.e., a single dose). Effects of placebo and GSE (300 mg) on systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), total vascular conductance (TVC), and rate × pressure product (RPP) in response to two submaximal cycling workloads (40% and 60% VO_2peak) were compared 2 h after ingestion of GSE or placebo on different days, 1 week apart. Endothelial function was also evaluated using flow-mediated dilation (FMD). Placebo treatment had no effect on any of the variables. GSE supplementation attenuated MAP at both workloads (40% VO_2peak: 115 ± 1 vs. 112 ± 2 mmHg; 60% VO_2peak: 126 ± 2 vs. 123 ± 2 mmHg) and RPP at the lower workload. Conversely, SV, CO, and TVC were augmented during both workloads. FMD was augmented by GSE (18.9 ± 2.0 vs. 12.4% ± 2.0%). These findings indicate that in exercising prehypertensive males, a single dose of GSE reduces blood pressure, peripheral vasoconstriction, and work of the heart and enhances O₂ delivery; effects that may be due, in part, to endothelium-dependent vasodilation. We propose that acute GSE treatment represents an intervention that may minimize potential increases in the risk of cardiovascular events during dynamic exercise in prehypertensives.

Research Insights

Red Grape→Improved Vascular Endothelial Function
FMD was augmented by GSE (18.9 ± 2.0 vs. 12.4% ± 2.0%)
Effect
Beneficial
Effect size
Moderate
Dose
300 mg
Red Grape→Increased Cardiac Output
SV, CO, and TVC were augmented during both workloads
Effect
Beneficial
Effect size
Small
Dose
300 mg
Red Grape→Increased Stroke Volume
SV, CO, and TVC were augmented during both workloads
Effect
Beneficial
Effect size
Small
Dose
300 mg
Red Grape→Increased Total Vascular Conductance
SV, CO, and TVC were augmented during both workloads
Effect
Beneficial
Effect size
Small
Dose
300 mg
Red Grape→Reduced Diastolic Blood Pressure
GSE supplementation attenuated MAP at both workloads (40% VO2peak: 115 ± 1 vs. 112 ± 2 mmHg; 60% VO2peak: 126 ± 2 vs. 123 ± 2 mmHg)
Effect
Beneficial
Effect size
Small
Dose
300 mg
Red Grape→Reduced Mean Arterial Pressure
GSE supplementation attenuated MAP at both workloads (40% VO2peak: 115 ± 1 vs. 112 ± 2 mmHg; 60% VO2peak: 126 ± 2 vs. 123 ± 2 mmHg)
Effect
Beneficial
Effect size
Small
Dose
300 mg
Red Grape→Reduced Rate Pressure Product
RPP at the lower workload
Effect
Beneficial
Effect size
Small
Dose
300 mg
Red Grape→Reduced Systolic Blood Pressure
GSE supplementation attenuated MAP at both workloads...
Effect
Beneficial
Effect size
Small
Dose
300 mg