Lactobacillus acidophilus L-92 and Improved Immune Function

• The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review.

  • 2025-08-01
  • Systematic Review · n = 1,502
  • Iranian journal of medical sciences 50(8)
  • • Leila Maghsoumi-Norouzabad
    • Alireza Bagherzadeh-Karimi
    • Shabnam Aliakbari Majd
    • Leila Hosseini
    • Fatemeh Shahi

  • PubMed: 40861839
  • DOI: 10.30476/ijms.2024.102363.3525

  10 Insights on

  • Improved Immune Function

  • High evidence

  Some studies indicated increased levels of Bifidobacteria and SCFA with prebiotic supplementation or prebiotics-enriched food products.

  Effect

  Beneficial

  Effect size

  Small

• Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis.

  • 2016-07
  • RCT · n = 50
  • Journal of Dairy Science 99(7)
  • • Kozo Yamamoto
    • K. Yokoyama
    • Takehisa Matsukawa
    • Sayaka Kato
    • S. Kato
    • Kazuhisa Yamada
    • Tatsuhiko Hirota

  • PubMed: 27108169
  • DOI: 10.3168/jds.2015-10605

  11 Insights on

  • Improved Immune Function

  • High evidence
  • Rigorous Journal

  This study suggested that L-92 suppresses type-2-helper-T-cell-dominant inflammation by activating regulatory T cells and type 1 helper T cells.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Recent Research on the Role of Lactobacilli Probiotics in Cancer Management.

  • 2026-01-17
  • Review
  • Nutrients 18(2)
  • • See-Hyoung Park

  • PubMed: 41599910
  • DOI: 10.3390/nu18020297

  5 Insights on

  • Improved Immune Function

  • Moderate evidence
  • Rigorous Journal

  The strain is known to modulate immune responses, including enhancement of regulatory T cell activity and suppression of Th2-type immune reactions.

  Effect

  Beneficial

  Effect size

  Small

• Autoinducer 2 as a universal language in microbial consortia: decoding molecular mechanisms, ecological impacts, and application.

  • 2026-01-23
  • Review
  • Gut microbes 18(1)
  • • Shuyu Guo
    • Bingyong Mao
    • Xin Tang
    • Qiuxiang Zhang
    • Jianxin Zhao
    • Wei Chen
    • Shumao Cui

  • PubMed: 41574816
  • DOI: 10.1080/19490976.2026.2615494

  3 Insights on

  • Improved Immune Function

  • Low evidence

  It has been suggested that L-92 improves immune responses and modulates the immune system in ways associated with reduced allergic manifestations.

  Effect

  Beneficial

  Effect size

  Moderate

• Overview of the immunomodulatory role of bacterial probiotic-derived peptidoglycan: from molecular insights to therapeutic application.

  • 2026-02-26
  • Review
  • Frontiers in microbiology 17
  • • Omer Qutaiba B Allela
    • Abdulkareem Shareef
    • Hayder Naji Sameer
    • Ahmed Yaseen
    • Zainab H Athab
    • Mohaned Adil

  • PubMed: 41834851
  • DOI: 10.3389/fmicb.2026.1761985

  8 Insights on

  • Improved Immune Function

  • Low evidence

  growing evidence indicates that many of their beneficial effects are mediated by structural components rather than by viable microorganisms... probiotic-derived peptidoglycan has emerged as a key immunologically active molecule with a critical role in regulating both innate and adaptive immunity

  Effect

  Beneficial

  Effect size

  Moderate

• The Role of Quorum Sensing Mechanism in the Functional Properties of Lactic Acid Bacteria.

  • 2026-03-10
  • Review
  • Microorganisms 14(3)
  • • Annalaura Iodice
    • Giuseppina Tommonaro

  • PubMed: 41900377
  • DOI: 10.3390/microorganisms14030618

  2 Insights on

  • Improved Immune Function

  • Low evidence

  The strain Lactobacillus acidophilus L-92 has been reported to exert beneficial effects on allergic symptoms and immune regulation in humans.

  Effect

  Beneficial

  Effect size

  Small

• The role of fermented foods in maternal health during pregnancy and infant health during the first 1,000 days of life.

  • 2025-06-05
  • Review
  • Frontiers in nutrition 12
  • • Arun Pandiyan
    • Manoj Gurung
    • Bharath Kumar Mulakala
    • Sathish Kumar Ponniah
    • Laxmi Yeruva

  • PubMed: 40538587
  • DOI: 10.3389/fnut.2025.1581723

  2 Insights on

  • Improved Immune Function

  • Low evidence

  the impact of maternal consumption of fermented foods on mothers and offspring microbiota, immune system, and brain health outcomes

  Effect

  Beneficial

  Effect size

  Small

• Certain fermented dairy foods as a source of multibiotics and multimetabolites: a comprehensive review.

  • 2025-11-06
  • Review
  • Frontiers in nutrition 12
  • • Duygu Ağagündüz
    • Yasemin Ertaş Öztürk
    • Büşra Ayhan
    • Tuğçe Bulmuş-Tüccar
    • Çiler Özenir
    • Nazlıcan Erdoğan Gövez
    • Yesim Ozogul
    • Tuba Esatbeyoglu
    • Fatih Ozogul

  • PubMed: 41280398
  • DOI: 10.3389/fnut.2025.1678150

  5 Insights on

  • Improved Immune Function

  • Low evidence

  Accumulated literature suggests that fermented dairy products are one of the important sources of some nutritional biotics like probiotics... have promising health effects

  Effect

  Beneficial

  Effect size

  Moderate

• Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.

  • 2025-05-07
  • Review
  • Microorganisms 13(5)
  • • Valentina Origüela
    • Alvaro Lopez-Zaplana

  • PubMed: 40431257
  • DOI: 10.3390/microorganisms13051084

  7 Insights on

  • Improved Immune Function

  • Low evidence

  The strain has been associated with immunomodulatory effects, including enhancement of regulatory T-cell responses and modulation of cytokine production.

  Effect

  Beneficial

  Effect size

  Small

• Probiotics in Pet Food: A Decade of Research, Patents, and Market Trends.

  • 2025-09-24
  • Review
  • Foods (Basel, Switzerland) 14(19)
  • • Phatthranit Klinmalai
    • Pitiya Kamonpatana
    • Janenutch Sodsai
    • Atcharawan Srisa
    • Khwanchat Promhuad
    • Yeyen Laorenza
    • Attawit Kovitvadhi
    • Sathita Areerat
    • Anusorn Seubsai
    • Massalin Nakphaichit
    • Nathdanai Harnkarnsujarit

  • PubMed: 41097477
  • DOI: 10.3390/foods14193307

  4 Insights on

  • Improved Immune Function

  • Low evidence

  probiotics hold clear potential to improve gastrointestinal health and immunity in pets

  Effect

  Beneficial

  Effect size

  Moderate

• Application of Probiotics in Cats and Dogs: Benefits and Mechanisms.

  • 2025-10-17
  • Review
  • Veterinary sciences 12(10)
  • • Jintao Sun
    • Xinshu Gu
    • Huaiyu Zhang
    • Lihong Zhao
    • Jinquan Wang
    • Xiumin Wang
    • Hui Tao
    • Zhenlong Wang
    • Bing Han

  • PubMed: 41150148
  • DOI: 10.3390/vetsci12101008

  14 Insights on

  • Improved Immune Function

  • Low evidence

  Specific probiotic strains exert their functions via mechanisms such as increasing immunoglobulin levels, suppressing the expression of inflammatory factors, and boosting antioxidant enzyme activity.

  Effect

  Beneficial

  Effect size

  Moderate

• Application of Probiotics in Foods: A Comprehensive Review of Benefits, Challenges, and Future Perspectives.

  • 2025-09-02
  • Review
  • Foods (Basel, Switzerland) 14(17)
  • • Mirjana Ž Grujović
    • Teresa Semedo-Lemsaddek
    • Katarina G Marković

  • PubMed: 40941204
  • DOI: 10.3390/foods14173088

  3 Insights on

  • Improved Immune Function

  • Low evidence

  Lactobacillus acidophilus L-92 was shown to modulate immune function, including suppression of Th2-dominant responses and enhancement of regulatory T-cell activity.

  Effect

  Beneficial

  Effect size

  Small