Recent Research on the Role of Lactobacilli Probiotics in Cancer Management.

2026-01-17
Nutrients 18(2)
- See-Hyoung Park

PubMed: 41599910
DOI: 10.3390/nu18020297

Study Design

Type: Review
Methods: review article

Rigorous Journal

Lactobacilli strains are one of the major groups belonging to probiotics. Lactobacilli strains are known to be beneficial microbes widely studied and utilized for their health benefits and applications in various fields. Recently, Lactobacilli strains have emerged as promising agents in cancer management due to their ability to influence various physiological processes. Lactobacilli strains have shown potential in producing tumor-suppressive compounds, enhancing immune responses, and reshaping gut microbiota balance for the management of various cancer types. Lactobacilli strains demonstrated tumor-suppressive activity through mechanisms including induction of apoptosis, inhibition of migration, and regulation of key oncogenic signaling pathways. However, the effects of Lactobacilli strains appear to be strain- and cancer-type-dependent, necessitating further research to identify the most effective strains for the proper cancer type with the optimal treatment regimens. In this review article, we focus on Lactobacilli strains studied between 2021 and 2025 that have demonstrated tumor-suppressive properties in various experimental models. In addition, this article explores the current limitations in research methodologies and proposes potential avenues for future investigations in this area of study.

Research Insights

Bifidobacterium plantarum→Improved Immune Response
have shown potential in producing tumor-suppressive compounds, enhancing immune responses, and reshaping gut microbiota balance for the management of various cancer types
Effect
Beneficial
Effect size
Moderate
Bifidobacterium plantarum→Increased Apoptosis
Lactobacilli strains demonstrated tumor-suppressive activity through mechanisms including induction of apoptosis, inhibition of migration, and regulation of key oncogenic signaling pathways
Effect
Beneficial
Effect size
Moderate
Bifidobacterium plantarum→Reduced Tumor Growth
have shown potential in producing tumor-suppressive compounds, enhancing immune responses, and reshaping gut microbiota balance for the management of various cancer types
Effect
Beneficial
Effect size
Moderate
Lactobacillus acidophilus L-92→Improved Immune Function
The strain is known to modulate immune responses, including enhancement of regulatory T cell activity and suppression of Th2-type immune reactions.
Effect
Beneficial
Effect size
Small
Lactobacillus acidophilus L-92→Reduced Allergic Symptoms
Lactobacillus acidophilus L-92 has been reported to suppress allergic responses and improve symptoms in subjects with cedar pollen allergy, atopic dermatitis, and allergic rhinitis.
Effect
Beneficial
Effect size
Moderate