Oral administration of Lactobacillus fermentum CRL1446 improves biomarkers of metabolic syndrome in mice fed a high-fat diet supplemented with wheat bran.

2021-03-23
Clinical Trial · n = 6
Food & Function 11(5)
- R. Medina
- Matías Russo
- Antonela Marquez
- Héctor M. Herrera
- M. C. Abeijón-Mukdsi
- L. Saavedra
- E. Hebert
- Paola Gauffin-Cano

PubMed: 32421119
DOI: 10.1039/d0fo00730g

Improved Insulin Sensitivity

Low evidence
Animal Study

On the other hand, L. fermentum CRL1446 reduced fasting glucose and insulin levels, improving the HOMA index in mice with MS.

Effect: Beneficial
Effect size: Moderate

The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats.

2019-12
Nutrition, Metabolism and Cardiovascular Diseases 29(12)
- R. G. S. Cavalcante
- Thatyane Mariano Rodrigues de Albuquerque
- M. O. de Luna Freire
- Georgianna de Araújo Henriques Ferreira
- L. A. Carneiro dos Santos
- M. Magnani
- J. Cruz
- V. Braga
- E. L. de Souza
- J. L. de Brito Alves

PubMed: 31640890
DOI: 10.1016/J.NUMECD.2019.08.003

10 Insights on

Improved Insulin Sensitivity

Low evidence

The results showed that rats fed with HF diet displayed insulin resistance... The administration of L. fermentum 296 for 4 weeks recovered fecal Lactobacillus sp. counts and alleviated hyperlipidemia, sympathetic hyperactivity, and reduced systolic blood pressure.

Effect: Beneficial
Effect size: Moderate