Across 3 studies, all reported beneficial effects on reducing waist circumference, with effect sizes ranging from small (two studies) to moderate (one study). Two of three studies found statistically significant reductions, and the evidence primarily comes from randomized controlled trials and a meta-analysis in obese adults. Doses were not consistently reported across studies.
Caveats: The evidence is based on three studies with relatively small sample sizes (total <210 participants). Doses were not consistently reported, limiting dose-response conclusions. One study did not explicitly report statistical significance. Larger, well-designed trials with standardized dosing and longer follow-up are needed to confirm the effect size and clinical relevance.
Decrease of waist and hip circumferences in the BNR17 group was more pronounced than those in the placebo group.
Significant reductions were observed in ... waist circumference (MD: -1.41 cm; 95%CI: -1.75-(-1.08), p<0.00001)
Waist circumferences were significantly decreased in both the BNR-L and BNL-H groups (P = .045 and .012, respectively) compared with the baseline values, but not in the placebo group.