Skip to main content

Effect of Lactobacillus gasseri BNR17 on Overweight and Obese Adults: A Randomized, Double-Blind Clinical Trial

  • 2013
  • Korean Journal of Family Medicine 34(2)
    • Seung-Pil Jung
    • Keun-Mi Lee
    • Ji-hee Kang
    • S. Yun
    • Han-Oh Park
    • Yong Moon
    • Jong-Yeon Kim

Abstract

Background: Lactobacillus gasseri BNR17 is a type of probiotic strain isolated from human breast milk. A study was reported regarding the fact that BNR17 was an inhibitor of obesity and diabetic activities in the human body through previous animal experiments. This study was furthered to investigate the effect of BNR17, a probiotic strain isolated from human breast milk, on obese and overweight adults.

Methods: Sixty-two obese volunteers aged 19 to 60 with body mass index ≥ 23 kg/m(2) and fasting blood sugar ≥ 100 mg/dL participated in a placebo controlled, randomized, and double-blind trial. For 12 weeks, 57 participants were given either placebo or BNR17 and were tested by measuring body fat, body weight, various biochemical parameters, vital signs, and computed tomography at the start of the study and at weeks 4, 8, and 12. The subjects assumed usual daily activities without having to make behavioral or dietary modifications during the course of the study.

Results: At the 12th week, a slight reduction in body weight was noted in the BNR17 group, but there were no significant weight changes between groups. Decrease of waist and hip circumferences in the BNR17 group was more pronounced than those in the placebo group. The two groups had no special or severe adverse reactions.

Conclusion: Despite there being no change in behavior or diet, administration of only the supplement of BNR17 reduced weight and waist and hip circumference. However, there were no significant differences between the two groups. These findings warrant a subsequent longer-term prospective clinical investigation with a large population.

Keywords: Human Breast Milk; Metabolic Disorders; Obesity; Probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus gasseriReduced Body WeightBeneficial
Small
Lactobacillus gasseriReduced Hip CircumferenceBeneficial
Small
Lactobacillus gasseriReduced Waist CircumferenceBeneficial
Small
Lactobacillus gasseri BNR17Reduced Body WeightBeneficial
Small
Lactobacillus gasseri LAC-343Absence of Severe Adverse ReactionsNeutral
Moderate
Lactobacillus gasseri LAC-343No Significant Weight ChangeNeutral
Small
Lactobacillus gasseri LAC-343Reduced Body WeightBeneficial
Small
Lactobacillus gasseri LBV 150NAbsence of Severe Adverse ReactionsNeutral
Moderate
Lactobacillus gasseri LBV 150NNo Significant Weight ChangeNeutral
Small
Lactobacillus gasseri LBV 150NReduced Body WeightBeneficial
Small
Lactobacillus gasseri SD-5585Reduced Body WeightBeneficial
Small
⬆ Back to top
Pillser
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.
Receive updates about our products, services, sales, and special offers. Unsubscribe anytime. See our Privacy Policy for details on how we handle your information.

Join Our Community

Use support@pillser.com to get in touch.