Lactobacillus plantarum DR7 and Improved Lipid Metabolism

• Lactobacillus plantarum-Derived Postbiotics Ameliorate Acute Alcohol-Induced Liver Injury by Protecting Cells from Oxidative Damage, Improving Lipid Metabolism, and Regulating Intestinal Microbiota

  • 2023-02-07
  • Clinical Trial
  • Nutrients 15(4)
  • • Wei Ye
    • Zengqiang Chen
    • Zhuoqi He
    • Haochen Gong
    • J. Zhang
    • Jiajun Sun
    • Shan Yuan
    • Junjie Deng
    • Yanlong Liu
    • Aibing Zeng

  • PubMed: 36839205
  • DOI: 10.3390/nu15040845

  12 Insights on

  • Improved Lipid Metabolism

  • Low evidence
  • Animal Study

  In the LP-cs-presupplemented mice, the genes involved in fatty acid metabolic processes were upregulated and the genes involved in steroid biosynthesis were downregulated significantly as compared with the ALI mice.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

  • 2020-03-26
  • RCT · n = 3
  • Frontiers in Microbiology 11
  • • Huizhen Li
    • Fei Liu
    • Jingjing Lu
    • Jialu Shi
    • Jiaqi Guan
    • Fenfen Yan
    • Bailiang Li
    • G. Huo

  • PubMed: 32273874
  • DOI: 10.3389/fmicb.2020.00512

  14 Insights on

  • Improved Lipid Metabolism

  • Low evidence
  • Highly Cited
  • Animal Study

  Moreover, the mixed lactobacilli supplementation significantly inhibited lipid accumulation in the liver and regulated lipid metabolism in epididymal fat pads.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Effects of skim milk fermented with Lactobacillus plantarum WW on the constitutions of rats fed a high-fat diet.

  • 2020-06
  • RCT
  • Journal of Dairy Science 103(6)
  • • Yang Li
    • Junrui Wu
    • Chengxu Cao
    • Xinyuan Zhu
    • Xueting Sun
    • R. Wu

  • PubMed: 32278555
  • DOI: 10.3168/jds.2019-17560

  21 Insights on

  • Improved Lipid Metabolism

  • Low evidence
  • Rigorous Journal
  • Animal Study

  real-time quantitative PCR and Western blot analysis showed that the probiotic was also involved in the expression of genes related to fat metabolism, especially the PPARB and CEBPB genes.

  Effect

  Beneficial

  Effect size

  Large