Lactobacillus plantarum UALp-05M and Reduced Inflammation Levels

Research synthesisLow evidenceLarge effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 preclinical studies (2 in vitro, 1 in vivo), all reported beneficial effects of Lactobacillus plantarum strains on reducing inflammatory markers, with effect sizes ranging from moderate to large. The single statistically significant study (in Caco-2 cells) showed large inhibition of pro-inflammatory cytokines. No human trials or consistent dosing data were available.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). All studies were preclinical (in vitro or animal models), and findings may not translate to humans.

Generated Jun 11, 2026

3 of 3 papersPopulation:

Evaluation of probiotic properties of Lactobacillus plantarum WLPL04 isolated from human breast milk.
- 2016-03
- Journal of Dairy Science 99(3)
- - Meiling Jiang
  - Fen Zhang
  - C. Wan
  - Yonghua Xiong
  - N. Shah
  - Hua Wei
  - X. Tao
- PubMed: 26805974
- DOI: 10.3168/jds.2015-10434
10 Insights on
- Reduced Inflammation Levels
- Moderate evidence
- Highly Cited
- Rigorous Journal
Lb. plantarum WLPL04 significantly inhibited the expression of inflammatory cytokines (IL-6, IL-8 and tumor necrosis factor-α) on Caco-2 cells but increased IL-10 expression in vitro compared with the Salmonella-treated group.
Effect
Beneficial
Effect size
Large
Significant
Yes
Lactobacillus plantarum BSGP201683 Isolated from Giant Panda Feces Attenuated Inflammation and Improved Gut Microflora in Mice Challenged with Enterotoxigenic Escherichia coli
- 2017-09-26
- Frontiers in Microbiology 8
- - Qian Liu
  - Xueqin Ni
  - Qiang Wang
  - Zhirong Peng
  - L. Niu
  - Hengsong Wang
  - Yi Zhou
  - Hao Sun
  - Kangcheng Pan
  - Bo Jing
  - Dong Zeng
- PubMed: 29018435
- DOI: 10.3389/fmicb.2017.01885
7 Insights on
- Reduced Inflammation Levels
- Low evidence
Results showed that *L. plantarum* G83 supplementation protected the mouse gut mainly by attenuating inflammation and improving the gut microflora.
Effect
Beneficial
Effect size
Large
Protective Effects of a Novel Probiotic Strain of Lactobacillus plantarum JSA22 from Traditional Fermented Soybean Food Against Infection by Salmonella enterica Serovar Typhimurium.
- 2015-04-28
- Journal of Microbiology and Biotechnology 25(4)
- - J. Eom
  - Jin Song
  - H. Choi
- PubMed: 25639720
- DOI: 10.4014/JMB.1501.01006
11 Insights on
- Reduced Inflammation Levels
- Low evidence
- Clinical
coincubation of S. Typhimurium and L. plantarum JSA22 with intestinal epithelial cells suppressed S. Typhimurium-induced NF-kappaB activation, and IL-8 production.
Effect
Beneficial
Effect size
Moderate

Lactobacillus plantarum UALp-05M and Reduced Inflammation Levels

Evaluation of probiotic properties of Lactobacillus plantarum WLPL04 isolated from human breast milk.

Lactobacillus plantarum BSGP201683 Isolated from Giant Panda Feces Attenuated Inflammation and Improved Gut Microflora in Mice Challenged with Enterotoxigenic Escherichia coli

Protective Effects of a Novel Probiotic Strain of Lactobacillus plantarum JSA22 from Traditional Fermented Soybean Food Against Infection by Salmonella enterica Serovar Typhimurium.