Lactobacillus rhamnosus MAK79L08R and Improved Intestinal Barrier Function

• Thirty Years of Lactobacillus rhamnosus GG: A Review.

  • 2019-03
  • Systematic Review
  • Journal of Clinical Gastroenterology 53(Supplement 1)
  • • L. Capurso

  • PubMed: 30741841
  • DOI: 10.1097/MCG.0000000000001170

  42 Insights on

  • Improved Intestinal Barrier Function

  • High evidence
  • Highly Cited

  LGG is able to produces both a biofilm that can mechanically protect the mucosa, and different soluble factors beneficial to the gut by enhancing intestinal crypt survival, diminishing apoptosis of the intestinal epithelium, and preserving cytoskeletal integrity.

  Effect

  Beneficial

  Effect size

  Large

• Lactobacillus rhamnosus attenuates Thai chili extracts induced gut inflammation and dysbiosis despite capsaicin bactericidal effect against the probiotics, a possible toxicity of high dose capsaicin

  • 2021-12-23
  • RCT
  • PLOS ONE 16(12)
  • • Wimonrat Panpetch
    • Peerapat Visitchanakun
    • Wilasinee Saisorn
    • A. Sawatpanich
    • Piraya Chatthanathon
    • N. Somboonna
    • S. Tumwasorn
    • A. Leelahavanichkul

  • PubMed: 34941893
  • DOI: 10.1371/journal.pone.0261189

  16 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Rigorous Journal
  • Animal Study
  • Mixed

  Both L34 and LGG attenuated gut barrier defect (FITC-dextran, the fluorescent staining and gene expression of tight junction molecules)

  Effect

  Beneficial

  Effect size

  Moderate

• Lactobacillus rhamnosus GG Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction by Regulating MAPK/NF-κB Signaling and Modulating Metabolome in the Piglet Intestine.

  • 2020-05
  • RCT · n = 6
  • The Journal of Nutrition 150(5)
  • • Jiangdi Mao
    • Siri Qi
    • Yanjun Cui
    • Xiaoxiao Dou
    • Xin M. Luo
    • Jianxin Liu
    • T. Zhu
    • Yanfei Ma
    • Haifeng Wang

  • PubMed: 32027752
  • DOI: 10.1093/jn/nxaa009

  9 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study
  • Clinical

  LGG pretreatment significantly enhanced the intestinal barrier by upregulating expressions of tight junction proteins (ZO-1, 73%; claudin-3, 55%; occludin, 67%); thereby decreasing serum diamineoxidase (26%) and D-xylose (28%) concentrations.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes