Pediococcus pentosaceus MAK99P15P and Reduced Inflammation Levels

• Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish

  • 2023-02-01
  • Clinical Trial
  • Frontiers in Nutrition 10
  • • Yue Liu
    • D-L Zhu
    • Jiwen Liu
    • X. Sun
    • Feng Gao
    • Hui-Ping Duan
    • Lina Dong
    • Xin Wang
    • Changxing Wu

  • PubMed: 36819708
  • DOI: 10.3389/fnut.2023.1087703

  15 Insights on

  • Reduced Inflammation Levels

  • Low evidence
  • Animal Study

  Probiotic suppressed HFD-induced inflammation by decreasing the expressions of IL-1b and IL-6. Levels of hepatic TNF-α, IL-1ß, and IL-6 were reduced by probiotic in HFD-fed zebrafish.

  Effect

  Beneficial

  Effect size

  Large

• Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice.

  • 2020-12-10
  • Clinical Trial
  • Journal of Agricultural and Food Chemistry 68(51)
  • • Yu Wang
    • Ying You
    • Yuan Tian
    • Haiyue Sun
    • Xia Li
    • Xiujuan Wang
    • Yuhua Wang
    • Jingsheng Liu

  • PubMed: 33300795
  • DOI: 10.1021/acs.jafc.0c05060

  10 Insights on

  • Reduced Inflammation Levels

  • Low evidence
  • Animal Study

  The treatment of P. pentosaceus PP04 reduced the gain of... lipopolysaccharides (LPS), and tumor necrosis factor-α (TNF-α)... significantly.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism

  • 2020-10-28
  • RCT · n = 28
  • World Journal of Gastroenterology 26(40)
  • • Xianwan Jiang
    • Yating Li
    • Jian-zhong Ye
    • L. Lv
    • Liya Yang
    • Xiaoyuan Bian
    • Wen-rui Wu
    • Jingjing Wu
    • D. Shi
    • Qing Wang
    • D. Fang
    • Kaicen Wang
    • Qiangqiang Wang
    • Yanmeng Lu
    • Jiaojiao Xie
    • Lanjuan Li

  • PubMed: 33177795
  • DOI: 10.3748/wjg.v26.i40.6224

  9 Insights on

  • Reduced Inflammation Levels

  • Low evidence
  • Rigorous Journal
  • Animal Study

  These changes were accompanied by decreased levels of endotoxin and inflammatory cytokines, including interleukin-5, tumor necrosis factor-α, granulocyte colony-stimulating factor, keratinocyte-derived protein chemokine, macrophage inflammatory protein-1α and monocyte chemoattractant protein-1.

  Effect

  Beneficial

  Effect size

  Large

• Whole-genome sequence assembly of Pediococcus pentosaceus LI05 (CGMCC 7049) from the human gastrointestinal tract and comparative analysis with representative sequences from three food-borne strains

  • 2014-08
  • Gut Pathogens 6(1)
  • • L. Lv
    • Yudong Li
    • Xin-Jun Hu
    • Hai-Yan Shi
    • Lan-Juan Li

  • PubMed: 25349631
  • DOI: 10.1186/s13099-014-0036-y

  5 Insights on

  • Reduced Inflammation Levels

  • Low evidence

  Some have been reported to reduce inflammation, encephalopathy, obesity and fatty liver in animals.

  Effect

  Beneficial

  Effect size

  Moderate