When considering Vitamin D3 supplementation, both daily and weekly regimens have been explored for their efficacy and compliance benefits¹².

Daily supplementation of Vitamin D3 is generally more effective in consistently maintaining higher serum levels of 25-hydroxyvitamin D compared to weekly or monthly dosing³. This effectiveness is particularly important for elderly individuals who may be at risk of falls and fractures¹.

However, weekly dosing may improve compliance, as it is easier for some people to remember a once-a-week dose compared to a daily one. Despite this potential benefit, weekly regimens might not sustain serum Vitamin D levels as effectively as daily supplementation².

Overall, daily administration seems to be preferable for maintaining optimal Vitamin D levels, whereas weekly dosing might enhance adherence to the supplementation schedule. It's worth noting that the choice of regimen should ideally consider individual compliance and health status.

Footnotes

1. Luca Dalle Carbonare, "Vitamin D: Daily vs. Monthly Use in Children and Elderly—What Is Going On?", PMC, 2024. ↩ ↩²

2. V. Chel, "Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents", PMC, 2007. ↩ ↩²

3. Laura Tripkovic, "Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis", PubMed, 2012. ↩