Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity
- 2017-05-31
- Nutrients 9(6)
- Ayoung Lee
- Young Ju Lee
- H. J. Yoo
- Minkyung Kim
- Yeeun Chang
- Dong Seog Lee
- J. H. Lee
- PubMed: 28561762
- DOI: 10.3390/nu9060558
Abstract
The aim of this study was to investigate the impact of consuming dairy yogurt containing Lactobacillus paracasei ssp. paracasei (L. paracasei), Bifidobacterium animalis ssp. lactis (B. lactis) and heat-treated Lactobacillus plantarum (L. plantarum) on immune function. A randomized, open-label, placebo-controlled study was conducted on 200 nondiabetic subjects. Over a twelve-week period, the test group consumed dairy yogurt containing probiotics each day, whereas the placebo group consumed milk. Natural killer (NK) cell activity, interleukin (IL)-12 and immunoglobulin (Ig) G1 levels were significantly increased in the test group at twelve weeks compared to baseline. Additionally, the test group had significantly greater increases in serum NK cell activity and interferon (IFN)-γ and IgG1 than placebo group. Daily consumption of dairy yogurt containing L. paracasei, B. lactis and heat-treated L. plantarum could be an effective option to improve immune function by enhancing NK cell function and IFN-γ concentration (ClinicalTrials.gov: NCT03051425).
Keywords: IFN-γ; NK cell activity; immune function; probiotics.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium animalis | Improved Immune Cell Function | Beneficial | Large |
| Bifidobacterium animalis | Improved Immune Function | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis B420 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis B420 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis Bi-07 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis Bl-04 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis BL818 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis BLA80 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Bifidobacterium lactis BLA80 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis BLC-1 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis HA-194 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis ISS Bif | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis MAK16B42L | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis R101-8 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Bifidobacterium lactis R101-8 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis R101-8 | Increased IFN-γ Levels | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis UABla-12 | Improved Immune Function | Beneficial | Large |
| Bifidobacterium lactis VK2 | Elevated IgG1 Levels | Beneficial | Large |
| Bifidobacterium lactis VK2 | Improved Immune Cell Function | Beneficial | Large |
| Bifidobacterium plantarum | Elevated Immunoglobulin G1 Levels | Beneficial | Large |
| Bifidobacterium plantarum | Elevated Interleukin-12 Levels | Beneficial | Large |
| Bifidobacterium plantarum | Improved Natural Killer Cell Activity | Beneficial | Large |
| Bifidobacterium plantarum | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lacticaseibacillus paracasei Lpc-37 | Improved Immune Cell Function | Beneficial | Large |
| Lacticaseibacillus paracasei Lpc-37 | Improved Immune Function | Beneficial | Large |
| Lacticaseibacillus paracasei Lpc-37 | Increased IFN-γ Concentration | Beneficial | Moderate |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Improved Immune Function | Beneficial | Large |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Improved Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Increased Immunoglobulin G1 Levels | Beneficial | Large |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Increased Serum Interferon Gamma Levels | Beneficial | Moderate |
| Lactobacillus casei | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus casei | Improved Immune Function | Beneficial | Large |
| Lactobacillus casei PXN 37 | Improved Immune Function | Beneficial | Large |
| Lactobacillus casei PXN 37 | Improved Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus casei PXN 37 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus casei R0215 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus casei R0215 | Improved Immune Function | Beneficial | Large |
| Lactobacillus casei R0215 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus casei SD-5842 | Improved Immune Function | Beneficial | Large |
| Lactobacillus lactis LI-23 | Improved Immune Function | Beneficial | Large |
| Lactobacillus lactis LLa61 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei | Improved Immune Cell Function | Beneficial | Large |
| Lactobacillus paracasei | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei 431 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus paracasei 431 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei 431 | Increased IFN-γ Concentration | Beneficial | Moderate |
| Lactobacillus paracasei DSM 13434 | Improved Immune Cell Function | Beneficial | Large |
| Lactobacillus paracasei DSM 13434 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei DSM 13434 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus paracasei HA-196 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei HA-196 | Improved Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus paracasei HA-196 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus paracasei IMC 502 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus paracasei IMC 502 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei LPC09 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus paracasei LPC09 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei LPC09 | Increased IFN-γ Concentration | Beneficial | Moderate |
| Lactobacillus paracasei MCC1849 | Improved Immune Cell Function | Beneficial | Large |
| Lactobacillus paracasei MCC1849 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei SD5275 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus paracasei SD5275 | Increased Immunoglobulin G1 Levels | Beneficial | Large |
| Lactobacillus paracasei subsp. paracasei UALpc-04 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus paracasei subsp. paracasei UALpc-04 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei UALpc-04 | Improved Immune Function | Beneficial | Large |
| Lactobacillus paracasei UALpc-04 | Improved Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus paracasei UALpc-04 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus plantarum | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum 14D | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum 14D | Improved Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus plantarum 14D | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus plantarum DR7 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Elevated IgG1 Levels | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Improved Immune Cell Function | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Increased IFN-γ Concentration | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum HA-119 | Improved Immune Cell Function | Beneficial | Large |
| Lactobacillus plantarum HA-119 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum HA-119 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus plantarum KABP™-061 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus plantarum KABP™-061 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum KABP™-061 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus plantarum L-137 | Elevated Serum IFN-γ Levels | Beneficial | Large |
| Lactobacillus plantarum L-137 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus plantarum L-137 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum LP-01 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum LP-01 | Improved Natural Killer Cell Function | Beneficial | Large |
| Lactobacillus plantarum LP-01 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus plantarum Lp-115 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus plantarum Lp-115 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum Lp-115 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus plantarum LP09 | Elevated Immunoglobulin G1 Levels | Beneficial | Large |
| Lactobacillus plantarum LP09 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus plantarum LP09 | Increased IFN-γ Concentration | Beneficial | Moderate |
| Lactobacillus plantarum R1012 | Elevated Serum IFN-γ Levels | Beneficial | Large |
| Lactobacillus plantarum R1012 | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus plantarum R1012 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Enhanced Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus plantarum SD-5209 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum UALp-05 | Elevated IgG1 Levels | Beneficial | Large |
| Lactobacillus plantarum UALp-05 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum UALp-05 | Improved Natural Killer Cell Activity | Beneficial | Large |
| Lactobacillus plantarum UALp-05 | Increased Interferon-Gamma Levels | Beneficial | Large |
| Lactobacillus plantarum UALp-05M | Improved Immune Cell Function | Beneficial | Large |
| Lactobacillus plantarum UALp-05M | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Improved Immune Cell Function | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Improved Immune Function | Beneficial | Large |
| Lactobacillus plantarum WCFS1 | Improved Immune Function | Beneficial | Large |