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Evidence-Based Supplement Research
Evidence-Based Supplement Research

saccharomyces boulardii and Reduced Abdominal Pain

Research synthesisLow evidenceMixed effect size3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects of Saccharomyces boulardii on reducing abdominal pain, with one showing a large effect and one a small effect, while 1 study found neutral results. Both beneficial studies reached statistical significance. The evidence primarily comes from clinical populations with Helicobacter pylori infection, and the median study duration was 44 days. Effect sizes were mixed (small to large) across the limited number of studies.

  • Studied populations: children and adults with Helicobacter pylori infection (including those with non-ulcer dyspepsia)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive (2 of 3 studies beneficial) — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The single neutral study was a 2025 meta-analysis with lower evidence quality, which tempers confidence. Doses were not reported in any of the included studies, limiting dose-specific recommendations.

Generated Jun 9, 2026
Time to effect
Median: 6.3 weeks · IQR 6.3 weeks6.3 weeks · Range 6.3 weeks6.3 weeks — Reported in 1 of 3 studies
Safety in these studies
3 of 3 papers
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