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Evidence-Based Supplement Research
Evidence-Based Supplement Research

saccharomyces boulardii and Reduced Abdominal Pain

Research synthesisModerate evidenceMixed effect size6 studies · 5 beneficial · 1 neutral · 0 harmful

Across 6 studies, 5 reported beneficial effects on abdominal pain, with effect sizes ranging from small to large. Most evidence comes from clinical populations with Helicobacter pylori infection, and the median study duration was 29 days. The predominant effect direction is beneficial, with effect sizes being mixed (small to large) across studies.

  • Studied populations: children and adults with Helicobacter pylori infection; patients with non-ulcer dyspepsia; patients with systemic sclerosis and small intestinal bacterial overgrowth

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies focused on H. pylori-infected populations, so generalizability to other causes of abdominal pain is uncertain. Dose information was often unreported, and study durations varied widely (10–60 days), limiting dose-response conclusions.

Generated Jul 10, 2026
Doses used in studies
  • mg/day: 500 (median 500, IQR 500500) 1 study
Time to effect
Median: 4.1 weeks · IQR 13 days6.9 weeks · Range 10 days8.6 weeks — Reported in 4 of 6 studies
Safety in these studies
6 of 6 papers
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