Lactobacillus paracasei VPro 224 and Reduced Salivary Levels of Mutans Streptococci

Research synthesisModerate evidenceModerate effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 randomized controlled trials, all reported beneficial effects of Lactobacillus paracasei VPro 224 on reducing salivary mutans streptococci levels, with effect sizes ranging from moderate to large. The majority of studies were conducted in children (3 of 4). No specific dose or form was consistently reported.

Studied populations: Children (preschool and school-age); one study in healthy adults (20–26 years)

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). No dose or form data were reported, and study durations were not consistently recorded, limiting the ability to determine optimal usage.

Generated Jul 11, 2026

4 of 4 papersPopulation:

Effect of Long-Term Consumption of Lactobacillus paracasei SD1 on Reducing Mutans streptococci and Caries Risk: A Randomized Placebo-Controlled Trial
- 2015-04-01
- RCT · n = 122
- Dentistry Journal 3(2)
- - R. Teanpaisan
  - S. Piwat
  - S. Tianviwat
  - B. Sophatha
  - Thanyanan Kampoo
- PubMed: 29567924
- DOI: 10.3390/dj3020043
9 Insights on
- Reduced Salivary Levels of Mutans Streptococci
- High evidence
- Rigorous Journal
- Children
Significantly reduced MS counts and increased lactobacilli levels were found among children in the probiotic group.
Effect
Beneficial
Effect size
Large
Significant
Yes
Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora
- 2010-05-26
- RCT · n = 78
- Clinical Oral Investigations 15(4)
- - L. Chuang
  - Chiung-Shing Huang
  - L. Ou-Yang
  - Shiao-Yu Lin
- PubMed: 20502929
- DOI: 10.1007/s00784-010-0423-9
4 Insights on
- Reduced Salivary Levels of Mutans Streptococci
- High evidence
- Highly Cited
- Rigorous Journal
- Adults
However, a significant count reduction in the salivary S. mutans was detected between T2 and T3 (p = 0.016).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Increasing salivary IgA and reducing Streptococcus mutans by probiotic Lactobacillus paracasei SD1: A double-blind, randomized, controlled study
- 2019-06
- RCT · n = 40
- Journal of Dental Sciences 14(2)
- - Nuntiya Pahumunto
  - B. Sophatha
  - S. Piwat
  - R. Teanpaisan
- PubMed: 31210892
- DOI: 10.1016/j.jds.2019.01.008
6 Insights on
- Reduced Salivary Levels of Mutans Streptococci
- High evidence
- Rigorous Journal
- Children
TS and *S. mutans* levels were significantly lower in the probiotic compared to the control group.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Reducing mutans streptococci and caries development by Lactobacillus paracasei SD1 in preschool children: a randomized placebo-controlled trial
- 2018-03-22
- RCT · n = 124
- Acta Odontologica Scandinavica 76(5)
- - Nuntiya Pahumunto
  - S. Piwat
  - O. Chankanka
  - N. Akkarachaneeyakorn
  - Karnrawee Rangsitsathian
  - R. Teanpaisan
- PubMed: 29566582
- DOI: 10.1080/00016357.2018.1453083
4 Insights on
- Reduced Salivary Levels of Mutans Streptococci
- High evidence
- Mixed
Children in the probiotic group had a significantly lower risk of an increase in the MS level than in the control group after receiving the probiotic milk at 3- and 4-months with p < .001 and p = .040, respectively.
Effect
Beneficial
Effect size
Moderate
Significant
Yes

Lactobacillus paracasei VPro 224 and Reduced Salivary Levels of Mutans Streptococci

Effect of Long-Term Consumption of Lactobacillus paracasei SD1 on Reducing Mutans streptococci and Caries Risk: A Randomized Placebo-Controlled Trial

Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora

Increasing salivary IgA and reducing Streptococcus mutans by probiotic Lactobacillus paracasei SD1: A double-blind, randomized, controlled study

Reducing mutans streptococci and caries development by Lactobacillus paracasei SD1 in preschool children: a randomized placebo-controlled trial