Lactobacillus plantarum UALp-05M and Improved Intestinal Barrier Function

• Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier.

  • 2010-06
  • RCT
  • American Journal of Physiology-Gastrointestinal and Liver Physiology 298(6)
  • • J. Karczewski
    • F. Troost
    • I. Konings
    • J. Dekker
    • M. Kleerebezem
    • R. Brummer
    • J. Wells

  • PubMed: 20224007
  • DOI: 10.1152/ajpgi.00327.2009

  9 Insights on

  • Improved Intestinal Barrier Function

  • High evidence
  • Highly Cited

  Lactobacillus plantarum, a commensal bacterium of humans, has been proposed to enhance the intestinal barrier, which is compromised in a number of intestinal disorders.

  Effect

  Beneficial

  Effect size

  Moderate

• Effect of Lactobacillus plantarum on diarrhea and intestinal barrier function of young piglets challenged with enterotoxigenic Escherichia coli K88.

  • 2014-04-01
  • Journal of Animal Science 92(4)
  • • K. M. Yang
    • Zong-yong Jiang
    • C. Zheng
    • Li Wang
    • X. Yang

  • PubMed: 24492550
  • DOI: 10.2527/jas.2013-6619

  6 Insights on

  • Improved Intestinal Barrier Function

  • Moderate evidence
  • Highly Cited
  • Rigorous Journal

  L. plantarum, given to piglets in early life, improved performance and effectively prevented the diarrhea in young piglets induced by ETEC K88 challenge by improving function of the intestinal barrier by protecting intestinal morphology and intestinal permeability and the expression of genes for tight junction proteins (zonula occludens-1 and occludin).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• The ameliorative effect of Lactobacillus plantarum-12 on DSS-induced murine colitis.

  • 2021-05-28
  • Clinical Trial
  • Food & Function 11(6)
  • • Mengying Sun
    • Yujun Liu
    • Yinglong Song
    • Yuan Gao
    • Fujunzhu Zhao
    • Yanghe Luo
    • Fang Qian
    • Guangqing Mu
    • Y. Tuo

  • PubMed: 32458908
  • DOI: 10.1039/d0fo00007h

  16 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study

  L. plantarum-12 administration could enforce the intestinal barrier function by up-regulating mucin 2 (MUC2) protein expression.

  Effect

  Beneficial

  Effect size

  Large

• Effects of probiotics Lactobacillus plantarum 16 and Paenibacillus polymyxa 10 on intestinal barrier function, antioxidative capacity, apoptosis, immune response, and biochemical parameters in broilers.

  • 2019-10
  • RCT · n = 540
  • Poultry Science 98(10)
  • • Yan-ping Wu
    • Baikui Wang
    • Zhonghua Zeng
    • Rongrong Liu
    • L. Tang
    • L. Gong
    • Wei-fen Li

  • PubMed: 31064013
  • DOI: 10.3382/ps/pez226

  8 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Highly Cited
  • Rigorous Journal
  • Animal Study

  The results revealed that both Lac16 and BSC10 maintained ileal mucosal morphology, and BSC10 regulated the expression of barrier function-related genes.

  Effect

  Beneficial

  Effect size

  Moderate

• Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets.

  • 2019-09-09
  • RCT · n = 60
  • Journal of Animal Physiology and Animal Nutrition 103(6)
  • • Qi Wang
    • Qian Sun
    • R. Qi
    • Jing Wang
    • Xiaoyu Qiu
    • Zuohua Liu
    • Jinxiu Huang

  • PubMed: 31498508
  • DOI: 10.1111/jpn.13198

  8 Insights on

  • Improved Intestinal Barrier Function

  • Low evidence
  • Animal Study

  L. plantarum 299v administration significantly increased the mRNA expression of jejunal occludin and ileal zonula occludens 1 (ZO-1). The L. plantarum treatment also increased the mRNA abundance of porcine β-defensin 2 (pBD2) and pBD3 in the jejunum and ileum and of toll-like receptors (TLRs), such as TLR2, TLR4, TLR6 and TLR9 in the ileum, and significantly upregulated the mRNA abundances of ileal pBD1 and colonic TLR4.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes