Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by the breakdown of joint cartilage and underlying bone, leading to symptoms like joint pain, stiffness, swelling, and decreased range of motion, most commonly affecting the fingers, thumbs, knees, hips, neck, and lower back. Risk factors include joint injury, obesity, aging, misaligned joints, and family history, with symptoms typically progressing slowly and potentially interfering with daily activities.
Health Outcomes
- Activated Wnt/Beta-Catenin Signaling
- Beneficial Clinical Effects
- Changed Leukocyte Telomere Length
- Changed Walking Cadence
- Decreased Vastus Medialis Thickness
- Delayed Time to First Analgesic Request
- Duration of Symptoms
- Elevated Serum Substance P Levels
- Enhanced Anti-inflammatory Properties
- Enhanced Anti-inflammatory Response
- Enhanced Antioxidant Enzyme Activity
- Enhanced Cell Viability Under Oxidative Stress
- Enhanced Inflammation Resolution
- Enhanced Inflammatory Response
- Improved 6-Meter Walk Performance
- Improved Activities of Daily Living
- Improved Agility Performance
- Improved Aging Symptom
- Improved Aging-Related Changes
- Improved Antioxidant and Anti-Inflammatory Response
- Improved Barthel Index Score
- Improved Bone Health
- Improved Daily Activity Participation
- Improved Distance Traveled
- Improved Ease of Use
- Improved Enjoyment of Life
- Improved Exercise Function
- Improved Five Times Sit-to-Stand Time
- Improved Flexed Arm Range of Motion
- Improved Function
- Improved Function Score
- Improved Functional Activity
- Improved Functional Ambulation Classification
- Improved Functional Outcome
- Improved Functional Recovery
- Improved Functional Status
- Improved Gait Speed
- Improved General Health Perception
- Improved Global Quality of Life
- Improved Global Symptom
- Improved Harris Hip Score
- Improved Health in Elderly Populations
- Improved Isokinetic Strength
- Improved Joint Function
- Improved KOA Symptoms
- Improved Knee Extensor Strength
- Improved Knee Joint Extensor Strength
- Improved Knee Muscle Strength
- Improved Leg Press Performance
- Improved Leg Press Strength
- Improved Leg Strength
- Improved Lower Body Endurance
- Improved Lower Body Power
- Improved Lower Body Strength
- Improved Lower Limb Peak Power
- Improved Lower-Body Strength and Power
- Improved Maximal Power
- Improved Maximal Walking Performance
- Improved Mechanical Properties
- Improved Mouth Opening Limitation
- Improved One Repetition Maximum Squat
- Improved Orthopedic Function
- Improved Overall Health
- Improved Overall Symptom Relief
- Improved Pain Intensity
- Improved Pain Management
- Improved Pain Scale
- Improved Pain Score
- Improved Pain Threshold
- Improved Patient Global Assessment
- Improved Patient Global Impression of Change (PGI-C) Scores
- Improved Patient Satisfaction
- Improved Peak Power
- Improved Perceived Health Status
- Improved Physical Activity Initiation
- Improved Physical Domain Score
- Improved Physical Function
- Improved Physical Health-Related Quality of Life
- Improved Physical Mobility
- Improved Physical Performance
- Improved Physical Quality of Life
- Improved Physical Role Limitation
- Improved Physician Global Assessment
- Improved Presenteeism
- Improved Pressure Pain Threshold
- Improved Quadriceps Endurance
- Improved Quadriceps Function
- Improved Quadriceps Strength
- Improved Quality of Life Score
- Improved Radiographic Success
- Improved Range of Motion
- Improved Role Physical
- Improved Self-assessed Disability
- Improved Serum Hyaluronan Levels
- Improved Specific Elements Within Assessed Measures
- Improved Standing Balance
- Improved Stiffness
- Improved Strain Index
- Improved Symptom Control in Degenerative Joint Disease
- Improved Symptom Relief
- Improved Symptom Severity
- Improved Symptoms
- Improved Tolerance
- Improved Vertical Jump Performance
- Improved Walking Ability
- Improved Walking Distance
- Improved Walking Speed
- Improved Wall-Squat Time
- Improved Western Ontario and McMaster Universities Osteoarthritis Index Total Score
- Increase in Persistent Diseased Sites
- Increased Analgesic Capacity
- Increased Anti-inflammatory Cytokines
- Increased Antioxidant Activity
- Increased Benefit Rate
- Increased Body Mass Index
- Increased Body Weight
- Increased Bone Density
- Increased Bone Formation/Resorption Ratio
- Increased Collagen Synthesis
- Increased EGF Level
- Increased Femoral Neck Bone Mineral Density
- Increased Hyaluronic Acid Molecular Weight
- Increased Hyaluronic Acid Production
- Increased Interleukin-1 Beta Production
- Increased Knee Extension Strength
- Increased MicroRNA-146a Expression
- Increased Mineralized Matrix Deposition
- Increased Muscle Cross-Sectional Area
- Increased Number of Pain-free Days
- Increased Osteoprotegerin Immunostaining
- Increased PTGS2 Expression
- Increased Pain
- Increased Pain-Free Days
- Increased Perceived Pain
- Increased Physical Activity
- Increased Plasma Vitamin K Levels
- Increased Walking Speed
- Maintained Morphological Integrity
- Maintained Physical Activity Level
- Maintained Physical Performance
- Maintained Vigorous Locomotion
- Modulated Nociceptive Signaling
- No Clear Clinical Benefit
- No Clear Effect on Systemic Inflammation
- No Conclusive Efficacy
- No Conclusive Long-Term Clinical Benefit
- No Difference in Adverse Events
- No Significant Change in Hip Joint Bone Mineral Density
- No Significant Change in Tumor Necrosis Factor Alpha Levels
- Normalized Serum IL-1β Levels
- Reduced Aging-related Changes
- Reduced Analgesic Usage
- Reduced Analgesic Use
- Reduced Arthralgia
- Reduced Arthritis Incidence
- Reduced Arthritis Score
- Reduced Arthritis Severity
- Reduced Arthritis Symptoms
- Reduced Average Pain
- Reduced Bodily Pain
- Reduced COX-2 Levels
- Reduced Cadence
- Reduced Cellular Senescence
- Reduced Clinical Symptoms of Arthritis
- Reduced Collagen Secretion
- Reduced Cyclooxygenase-2 Levels
- Reduced Disability
- Reduced Discomfort
- Reduced Disease Severity
- Reduced Hyaluronan Level
- Reduced Hyaluronidase Activity
- Reduced IL-1β Levels
- Reduced Impediment
- Reduced Inflammatory Pathways
- Reduced Interference Score
- Reduced Interference with Daily Life
- Reduced Interleukin-1β Levels
- Reduced Interleukin-6 Levels
- Reduced Intestinal Adenoma Incidence
- Reduced Joint Damage
- Reduced Joint Inflammation
- Reduced Joint Swelling
- Reduced Joint Tenderness
- Reduced Knee Pain
- Reduced Locomotor Impairment
- Reduced Mean Total Severity per Day in Reported Episodes
- Reduced Musculoskeletal Dysfunction
- Reduced Musculoskeletal Pain
- Reduced Opioid Consumption
- Reduced Overall Symptom Score
- Reduced Pain
- Reduced Pain Assessment Score
- Reduced Pain During Movement
- Reduced Pain Frequency
- Reduced Pain Intensity
- Reduced Pain Levels
- Reduced Pain Medication Use
- Reduced Pain Scale
- Reduced Pain Score
- Reduced Pain Sensitivity
- Reduced Pain Severity
- Reduced Pain Symptom Score
- Reduced Pain Symptoms
- Reduced Pain-Related Disability
- Reduced Painkiller Consumption
- Reduced Paw Volume
- Reduced Physical Activity
- Reduced Physical Symptoms
- Reduced Postoperative Complications
- Reduced Postoperative Fatigue
- Reduced Postoperative Pain
- Reduced Postoperative Pain Intensity
- Reduced Proinflammatory Mediators
- Reduced Quadriceps Muscle Cross-Sectional Area
- Reduced Release of Inflammatory Mediators (TNF-α, IL-6, IL-1β, IL-10)
- Reduced Senescence-Associated Secretory Phenotype
- Reduced Serum Collagen Type II C-Telopeptide (sCTX-II)
- Reduced Soreness
- Reduced Standard Care Medication Need
- Reduced Stiffness
- Reduced Substance P Levels
- Reduced Surface Skewness
- Reduced Swelling
- Reduced Swimming Time
- Reduced Symptom Severity Scale Score
- Reduced TRPV1 Activation
- Reduced Tissue Inhibitor of Metalloproteinase 1 Level
- Reduced Total Analgesic Dosage
- Reduced Total Morphine Consumption
- Reduced Treatment Costs
- Reduced Use of Pain Relieving Drugs
- Reduced WOMAC Function Score
- Reduced WOMAC Pain Score
- Reduced Walking Time
- Reduced Worst Pain
- Slowed Progression of Knee Osteoarthritis
- Strengthened Musculoskeletal System
- Supported Physiological Function in Elderly
- Unchanged Biochemical Parameters
- Unchanged Symptom Severity
- Upregulated Macrophage Inhibitory Factor
- Well-Tolerated Supplementation