July 2012 Supplement Research Papers

• July 1

  • Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury.

    • 2012-07-01
    • American journal of physiology. Gastrointestinal and liver physiology 303(1)
    • • Yuhua Wang
      • Yanlong Liu
      • Anju Sidhu
      • Zhenhua Ma
      • Craig McClain
      • Wenke Feng

    • PubMed: 22538402
    • DOI: 10.1152/ajpgi.00024.2012

    2 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Alcohol-Induced Liver Injury

    • Low evidence
    • Highly Cited
    • Animal Study
• July 15

  • Effect of Pueraria tuberosa DC. (Indian Kudzu) on blood pressure, fibrinolysis and oxidative stress in patients with stage 1 hypertension.

    • 2012-07-15
    • RCT · n = 15
    • Pakistan journal of biological sciences : PJBS 15(15)
    • • S K Verma
      • Vartika Jain
      • D P Singh

    • PubMed: 24171260
    • DOI: 10.3923/pjbs.2012.742.747

    4 Insights on

    • Reduced Fibrinogen Levels
    • Reduced Blood Pressure
    • Improved Total Antioxidant Status
    • Improved Fibrinolytic Activity

    • High evidence
• July 26

  • Lactobacillus acidophilus strain L-92 induces CD4(+)CD25(+)Foxp3(+) regulatory T cells and suppresses allergic contact dermatitis.

    • 2012-07-26
    • Clinical Trial
    • Biological and Pharmaceutical Bulletin 35(4)
    • • M. Shah
      • M. Saio
      • H. Yamashita
      • Hiroyuki Tanaka
      • T. Takami
      • T. Ezaki
      • N. Inagaki

    • PubMed: 22466569
    • DOI: 10.1248/BPB.35.612

    2 Insights on

    • Increased Regulatory T Cell Populations
    • Reduced Allergic Contact Dermatitis

    • Low evidence
    • Animal Study
• Undated – 4 supplement studies

  • Caenorhabditis elegans Immune Conditioning with the Probiotic Bacterium Lactobacillus acidophilus Strain NCFM Enhances Gram-Positive Immune Responses

    • 2012-07
    • Clinical Trial
    • Infection and Immunity 80(7)
    • • Younghoon Kim
      • E. Mylonakis

    • PubMed: 22585961
    • DOI: 10.1128/IAI.06350-11

    5 Insights on

    • Reduced Adhesion of Enterococcus faecalis
    • Increased Survival During Pathogenic Exposure
    • Enhanced Immune Response to Gram-Positive Bacteria
    • Minimal Effect on Gram-Negative Infections
    • Reduced Defense Gene Activity for Gram-Negative Pathogens

    • Low evidence
    • Highly Cited
    • Animal Study

  • Evaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule: a randomized control trial.

    • 2012-07
    • RCT · n = 131
    • Regulatory Toxicology and Pharmacology 63(2)
    • • M. Jones
      • C. Martoni
      • E. Di Pietro
      • R. Simon
      • S. Prakash

    • PubMed: 22561556
    • DOI: 10.1016/j.yrtph.2012.04.003

    4 Insights on

    • Absence of Adverse Effects
    • Changed Clinical Chemistry Parameter
    • Changed Hematology Parameter
    • Reduced Adverse Event Frequency

    • High evidence

  • Lack of an effect of Lactobacillus reuteri DSM 17938 in preventing nosocomial diarrhea in children: a randomized, double-blind, placebo-controlled trial.

    • 2012-07
    • RCT · n = 106
    • The Journal of Pediatrics 161(1)
    • • M. Wanke
      • H. Szajewska

    • PubMed: 22306046
    • DOI: 10.1016/j.jpeds.2011.12.049

    3 Insights on

    • Reduced Nosocomial Diarrhea Incidence
    • Reduced Rotavirus Infection Incidence
    • Incidence of Hospital-Acquired Diarrhea

    • High evidence

  • Increases in GroES and GroEL from Lactobacillus acidophilus L-92 in response to a decrease in medium pH, and changes in cytokine release from splenocytes: Transcriptome and proteome analyses.

    • 2012-07
    • Journal of Bioscience and Bioengineering 114(1)
    • • Rumiko Kuwana
      • N. Yamamoto

    • PubMed: 22417456
    • DOI: 10.1016/j.jbiosc.2012.02.010

    7 Insights on

    • Increased Cytokine Response
    • Reduced Allergic Symptoms
    • Improved Immunomodulation
    • Modulated Immune Response
    • Improved Immune Modulation
    • Increased Th1-Associated Cytokine Release
    • Improved Anti-Allergy-Related Cytokine Profile

    • Low evidence