J. Villena

Tohoku University

Research Areas

• Probiotics and Fermented Foods
• Immune Response and Inflammation
• Gut microbiota and health
• Pediatric health and respiratory diseases
• Viral gastroenteritis research and epidemiology

Health Outcomes Studied

• Increased Interferon-Gamma Levels
• Increased Interleukin-10 Levels
• Increased Serum Immunoglobulin A (IgA) Levels
• Reduced Interleukin-6 Levels
• Reduced Tumor Necrosis Factor Alpha

Papers (26)

• 2024
  Role of immunomodulatory probiotics in alleviating bacterial diarrhea in piglets: a systematic review.10.1186/s40104-024-01070-z
• 2022
  Soymilk-fermented with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L improves immune-health in pigs.10.3920/BM2021.0068
• 2020Primary author
  The Modulation of Mucosal Antiviral Immunity by Immunobiotics: Could They Offer Any Benefit in the SARS-CoV-2 Pandemic?10.3389/fphys.2020.00699
• 2020
  Nasal priming with immunobiotic lactobacilli improves the adaptive immune response against influenza virus.10.1016/j.intimp.2019.106115
• 2020
  Exopolysaccharides From Streptococcus thermophilus ST538 Modulate the Antiviral Innate Immune Response in Porcine Intestinal Epitheliocytes10.3389/fmicb.2020.00894
• 2020
  New immunobiotics from highly proteolytic Lactobacillus delbrueckii strains: their impact on intestinal antiviral innate immune response.10.3920/bm2019.0198
• 2019
  Nasal Priming with Lactobacillus rhamnosus CRL1505 Stimulates Mononuclear Phagocytes of Immunocompromised Malnourished Mice: Improvement of Respiratory Immune Response10.1007/s12602-019-09551-8
• 2018
  Draft Genome Sequences of Lactobacillus salivarius A3iob and Lactobacillus johnsonii CRL1647, Novel Potential Probiotic Strains for Honeybees (Apis mellifera L.)10.1128/MRA.00975-18
• 2018
  Are the immunomodulatory properties of Lactobacillus rhamnosus CRL1505 peptidoglycan common for all Lactobacilli during respiratory infection in malnourished mice?10.1371/journal.pone.0194034
• 2017
  Peptidoglycan from Immunobiotic Lactobacillus rhamnosus Improves Resistance of Infant Mice to Respiratory Syncytial Viral Infection and Secondary Pneumococcal Pneumonia10.3389/fimmu.2017.00948
• 2017
  Lactobacillus rhamnosus CRL1505 nasal administration improves recovery of T-cell mediated immunity against pneumococcal infection in malnourished mice.10.3920/BM2016.0152
• 2017
  Exopolysaccharide-producing Streptococcus thermophilus CRL1190 reduces the inflammatory response caused by Helicobacter pylori.10.3920/BM2016.0186
• 2015Primary author
  Immunobiotic Lactobacillus rhamnosus strains differentially modulate antiviral immune response in porcine intestinal epithelial and antigen presenting cells10.1186/1471-2180-14-126
• 2015
  Non-viable immunobiotic Lactobacillus rhamnosus CRL1505 and its peptidoglycan improve systemic and respiratory innate immune response during recovery of immunocompromised-malnourished mice.10.1016/j.intimp.2015.02.006
• 2014
  Modulation of the inflammation–coagulation interaction during pneumococcal pneumonia by immunobiotic Lactobacillus rhamnosus CRL1505: Role of Toll‐like receptor 210.1111/1348-0421.12163
• 2013
  Draft Genome Sequence of Lactobacillus rhamnosus CRL1505, an Immunobiotic Strain Used in Social Food Programs in Argentina10.1128/genomeA.00627-13
• 2013
  Lactobacillus rhamnosus CRL1505 beneficially modulates the immuno-coagulative response after pneumococcal infection in immunocompromised malnourished mice.10.1139/cjm-2013-0361
• 2013
  Nasally administered Lactobacillus rhamnosus accelerate the recovery of humoral immunity in B lymphocyte-deficient malnourished mice.10.3945/jn.112.165811
• 2013
  Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection.10.1016/j.intimp.2013.06.024
• 2012Primary author
  Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C)10.1186/1471-2172-13-53
• 2012
  Stimulation of macrophages by immunobiotic Lactobacillus strains: influence beyond the intestinal tract10.1111/j.1348-0421.2012.00495.x
• 2012
  Immunobiotic Lactobacillus jensenii Elicits Anti-Inflammatory Activity in Porcine Intestinal Epithelial Cells by Modulating Negative Regulators of the Toll-Like Receptor Signaling Pathway10.1128/IAI.05729-11
• 2011
  Development of a fermented goats' milk containing Lactobacillus rhamnosus: in vivo study of health benefits.10.1002/jsfa.4467
• 2010
  Immunomodulatory activity of Lactobacillus rhamnosus strains isolated from goat milk: impact on intestinal and respiratory infections.10.1016/j.ijfoodmicro.2010.03.013
• 2006
  Beneficial immunomodulatory activity of Lactobacillus casei in malnourished mice pneumonia: effect on inflammation and coagulation.10.1016/J.NUT.2006.03.013
• 2005Primary author
  Lactobacillus casei improves resistance to pneumococcal respiratory infection in malnourished mice.10.1093/JN/135.6.1462