Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder that primarily impairs cognitive functions, particularly memory, and is the leading cause of dementia, accounting for 60-70% of cases. It begins slowly and progressively worsens, leading to severe cognitive decline, loss of bodily functions, and ultimately death, with an average life expectancy of three to twelve years after diagnosis.
Health Outcomes
- Activated Mitophagy Pathway
- Activation of G-Protein Coupled Receptors
- Alleviated Clinical Outcomes
- Altered Neurobiological Markers
- Changed Brain Activity
- Changed Functional Connectivity
- Changed Leukocyte Telomere Length
- Confirmed Safety of Treatment
- Decreased Composite Scores
- Delayed Disease Progression
- Delayed Neurodegeneration
- Elevated Redox Status
- Elevated Serum Acetylcholine Levels
- Enhanced Antioxidant Activity
- Enhanced Antioxidant Enzyme Activity
- Enhanced Antioxidant Levels
- Enhanced Auto-aggregation Ability
- Enhanced Autophagy
- Enhanced BDNF-TrkB Signaling
- Enhanced Brain-Derived Neurotrophic Factor Levels
- Enhanced Caspase-3 Activity
- Enhanced Cognitive Function
- Enhanced Endoplasmic Reticulum Stress Response
- Enhanced Mitochondrial Biogenesis
- Enhanced Neurogenesis in Adults
- Enhanced Neurological Disorder Management
- Enhanced Neuropharmacological Function
- Enhanced Polyphenol Levels
- Enhanced Radical Scavenging Ability
- Enhanced Reactive Oxygen Species Resistance
- Enhanced Superoxide Dismutase Activity
- Facilitated Mitophagy
- Genome Sequencing / Genome Characterization
- Impaired Vacuolar Function
- Improved Activities of Daily Living
- Improved Activities of Daily Living Score
- Improved Agility and Coordination Performance
- Improved Aging Symptom
- Improved Aging-Related Changes
- Improved Alzheimer Disease
- Improved Alzheimer Disease Assessment Scale-Cognitive Subscale Score
- Improved Alzheimer Disease Assessment Scale-Noncognitive Subscale Score
- Improved Analytical Accuracy
- Improved Anti-Aging Effects
- Improved Antioxidant Activity
- Improved Antioxidant Capacity
- Improved Antioxidative Capacity
- Improved Antioxidative Response
- Improved Barthel Index
- Improved Barthel Index Score
- Improved Blood-Brain Barrier Function
- Improved Blood-Brain Barrier Integrity
- Improved Brain Activity
- Improved Brain Function
- Improved Brain Health
- Improved Brain-Derived Neurotrophic Factor Level
- Improved Catalase Activity
- Improved Catalase Level
- Improved Cell-Cell Signalling
- Improved Central Nervous System Function
- Improved Cerebral Blood Flow
- Improved Cerebral Blood Flow Velocity
- Improved Clinical Dementia Rating
- Improved Clinical Effective Rate
- Improved Clock Drawing Test Score
- Improved Cognition
- Improved Cognitive Behavior
- Improved Cognitive Flexibility
- Improved Cognitive Function
- Improved Cognitive Functioning
- Improved Cognitive Orientation Function
- Improved Cognitive Performance
- Improved Cognitive Prognosis
- Improved Cognitive Score
- Improved Cognitive Screen Score
- Improved Cognitive Speed
- Improved Cognitive Status
- Improved Communication
- Improved Constructional Praxis
- Improved Cytoprotection During Oxidative Stress
- Improved Decision Accuracy
- Improved Decision-Making Accuracy
- Improved Delayed Memory
- Improved Delayed Word Recall
- Improved Digit Symbol Substitution Test Score
- Improved Domain-Specific Cognition
- Improved Executive Function
- Improved Flexibility or Set Shift
- Improved Folate Level
- Improved Follistatin Level
- Improved Global Assessment
- Improved Global Assessment of Efficacy
- Improved Global Clinical Impression
- Improved Global Cognition
- Improved Global Cognitive Function
- Improved Glutathione Level
- Improved Glutathione Peroxidase Activity
- Improved Glutathione Peroxidase Level
- Improved Glutathione Redox Ratio
- Improved Gut Microbiota with Reversal of Alzheimer’s Disease-related Changes
- Improved Health in Elderly Populations
- Improved Healthy Aging
- Improved Hippocampal Fractional Anisotropy
- Improved Immediate Word Recall
- Improved Inhibitory Executive Process
- Improved Language Outcome
- Improved Language Score
- Improved MMSE Score
- Improved Mathematical Processing
- Improved Memory
- Improved Memory Complaint
- Improved Memory Function
- Improved Memory Performance
- Improved Mini-Mental State Examination Score
- Improved Mitochondrial Function
- Improved Neurodegenerative Disease Symptoms
- Improved Neurodegenerative Disorder
- Improved Neurological Health
- Improved Neurological Parameter
- Improved Neurological Symptoms
- Improved Neuronal Survival
- Improved Neuroplasticity Biomarkers
- Improved Neuroprotection
- Improved Neuropsychiatric Outcomes
- Improved Neurotransmitter Metabolism
- Improved Neurotransmitter Profile
- Improved Neurotrophic Signaling
- Improved Numeric Working Memory
- Improved Odor Discrimination Score
- Improved Orientation in Time (MMSE Subscale)
- Improved Overall Cognitive Function
- Improved Oxidative Stress Marker
- Improved Oxidative Stress Resistance
- Improved Oxidative Stress Tolerance
- Improved PRDX1 Gene Expression
- Improved Paired Associate Learning
- Improved Parent/Caregiver Quality of Life
- Improved Pattern Separation
- Improved Performance Mastery
- Improved Processing Speed
- Improved Recognition Memory
- Improved Redox Homeostasis
- Improved Redox Potential
- Improved Relative Mean Power
- Improved Responder Rate
- Improved Saliva Flow Rate
- Improved Serum Biochemical Catalase Levels
- Improved Set-Shifting Reaction Time
- Improved Short-term Memory
- Improved Simon Task Accuracy
- Improved Simulated Game Total Completion Time
- Improved Spatial Learning Ability
- Improved Spatial Working Memory
- Improved Stroop Color Test
- Improved Superoxide Dismutase Activity
- Improved Superoxide Dismutase Level
- Improved Synaptic Plasticity
- Improved Telephone Interview for Cognitive Status Score
- Improved Timed Up and Go Test
- Improved Timed Up-and-Go Test Performance
- Improved Trail Making Test Time
- Improved Verbal Episodic Memory
- Improved Verbal Fluency
- Improved Verbal Paired-Associate Learning
- Improved Visual Retention
- Improved Visual-Spatial Function
- Improved Visuo-Cognitive Processing
- Improved Visuospatial Constructional Skills
- Improved Wechsler Memory Scale Score
- Improved Working Memory
- Improved Working Memory Speed
- Increased 3-Hydroxykynurenine to Kynurenine Ratio
- Increased AMPK Activation
- Increased Abundance of Specific Anti-Alzheimer's Disease Bacteria
- Increased Acetylcholine Levels
- Increased Antioxidant Enzyme Levels
- Increased Apolipoprotein E Levels
- Increased Apoptosis
- Increased Autophagy
- Increased Bioavailability of Phenolics
- Increased Blood Homocysteine Level
- Increased Brain Choline Level
- Increased Catalase Expression
- Increased Catalase Level
- Increased Caveolin-1 Level
- Increased Cellular Apoptosis
- Increased Choline Level
- Increased Constipation Risk
- Increased Correct Answer Rate
- Increased Cysteine Level
- Increased DHA Level
- Increased DNA Damage
- Increased DNA Methylation
- Increased Delta Power in EEG
- Increased ER Stress-Associated Proteins
- Increased Expression of Heat Shock Protein 25
- Increased F2-Isoprostane Level
- Increased Fall Risk
- Increased GSH/GSSG Ratio
- Increased Glutathione Peroxidase Activity
- Increased Glutathione Peroxidase Levels
- Increased Glutathione Reductase Activity
- Increased Homocysteine Level
- Increased Humanin Level
- Increased Hydrogen Peroxide Production
- Increased Interleukin-1 Beta Production
- Increased Interleukin-1β Level
- Increased Malondialdehyde Levels
- Increased Maresin-1 Level
- Increased MicroRNA-146a Expression
- Increased Mortality
- Increased Mortality Rate
- Increased Myo-Inositol Level
- Increased Nerve Growth Factor Receptor Level
- Increased Neurogenesis
- Increased Neuronal Cell Survival
- Increased Osteopontin Level
- Increased Oxidative Stress
- Increased Oxidative Stress Tolerance
- Increased PTGS2 Expression
- Increased Plasma Kynurenic Acid Levels
- Increased Plasma Omega-3 Fatty Acids
- Increased Plasma Serum Alpha-Amyloid Protein
- Increased Polyphenol Level
- Increased Postsynaptic Density Protein 95 Levels
- Increased Prefrontal Cortex Deoxygenated Hemoglobin Level
- Increased Pro-inflammatory Cytokine Production
- Increased Reactive Oxygen Species Production
- Increased Reactive Oxygen Species Response
- Increased Serine Level
- Increased Serum NAD+ Levels
- Increased Superoxide Dismutase Activity
- Increased Tetrahydrobiopterin Level
- Increased Total Serum Antioxidant Capacity
- Increased Total Thiol Level
- Increased Tumor Necrosis Factor-Alpha Levels
- Increased Uncoupling Protein 2 Expression
- Increased miRNA-21 Expression
- Inhibited Activation of Apoptotic Biomarkers
- Maintained Acetylcholine Levels
- Maintained Cognitive Function
- Maintained or Improved Cognitive Function
- Modified Resting-State Brain Connectivity
- Modulated Metabolite Profile
- Modulated Signal Transduction Pathways
- Nervous System Dysfunction in Host
- Neuroprotection in Neurodegenerative Diseases
- No Change in Cytokines or Chemokines Levels
- No Change in Plasma GABA Levels
- No Change in Subjective Appetite
- No Significant Cognitive Improvement
- No Significant Impact on Bacterial Community Composition or Diversity
- No Significant Improvement in Memory Retention
- No Significant Weight Change
- Normalized Serum IL-1β Levels
- Preserved Hippocampal Neurogenesis
- Prevented Neurometabolic Decline
- Prevention of Neurological Disorders
- Protection Against Oxidative Stress
- Reduced 24-Hydroxycholesterol to Total Cholesterol Ratio
- Reduced 7-Hydroxycholesterol Level
- Reduced Accommodation Variability
- Reduced Adherence Attrition
- Reduced Age-Related Inflammation
- Reduced Aging-related Changes
- Reduced Agitation
- Reduced Alzheimer Disease Symptom
- Reduced Alzheimer's Disease-Associated Gut Dysbiosis
- Reduced Alzheimer's Disease-Related Neurotoxicity
- Reduced Alzheimer’s Disease Pathology
- Reduced Amnesia
- Reduced Amyloid Beta 40 Level
- Reduced Amyloid Beta 42 Level
- Reduced Amyloid Precursor Protein Level
- Reduced Amyloid Protein Level
- Reduced Amyloid-β Levels
- Reduced ApoE Level
- Reduced Apoptosis
- Reduced Apoptosis Signal-Regulating Kinase 1 Level
- Reduced BACE1 mRNA Level
- Reduced Behavioral Symptoms
- Reduced Brain Atrophy
- Reduced Brain Inflammation
- Reduced Brain Oxidative Stress
- Reduced CCL20 Level
- Reduced Carbonyl Group Level
- Reduced Catalase Activity
- Reduced Cellular Damage
- Reduced Cellular Senescence
- Reduced Central Nervous System Symptom Severity
- Reduced Cerebral Blood Flow
- Reduced Cerebral Blood Flow Velocity
- Reduced Choking Index
- Reduced Choline Level
- Reduced Coenzyme Q10 Level
- Reduced Cognitive Decline
- Reduced Cognitive Function
- Reduced Cognitive Function Test Score
- Reduced Cognitive Impairment
- Reduced Confusion
- Reduced Confusion and Bewilderment
- Reduced Confusion-Bewilderment T-Score
- Reduced Cortical Excitation
- Reduced Crying
- Reduced Cytoskeleton Disruption
- Reduced Dementia Incidence
- Reduced Dietary Advanced Glycation End Product Intake
- Reduced Digit Vigilance Task Error
- Reduced Disability
- Reduced Disease Progression
- Reduced Dysphagia Severity
- Reduced Dysphagia Symptom Score
- Reduced Endoplasmic Reticulum Stress Marker Level
- Reduced Expression of ADAM17
- Reduced Fall Occurrence
- Reduced Fall Rate
- Reduced Ferric Reducing Antioxidant Power
- Reduced Ferroptosis
- Reduced Folate Deficiency
- Reduced Free Radical Levels
- Reduced Glial Cell Activation
- Reduced Glutamate Level
- Reduced Glutathione Loss
- Reduced Glutathione Peroxidase Level
- Reduced Glutathione Redox Ratio
- Reduced Glycative Stress Marker Level
- Reduced Hippocampal Apoptosis
- Reduced Hydrogen Sulfide Level
- Reduced IL-1β Levels
- Reduced IkappaB Alpha Degradation
- Reduced Indoleamine 2,3-Dioxygenase Activity
- Reduced Inflammatory Biomarker Level
- Reduced Insulin/IGF-1 Signaling
- Reduced Interleukin-1β Levels
- Reduced Intracellular Adhesion Molecule-1 Level
- Reduced Kynurenine Level
- Reduced Kynurenine-Tryptophan Ratio
- Reduced Laminin Level
- Reduced Levels of Anti-Inflammatory Cytokines
- Reduced Lipid Peroxide Level
- Reduced Lipofuscin Accumulation
- Reduced Lymphocytic Genome Damage
- Reduced Lysophosphatidylcholine Level
- Reduced Lysophosphatidylethanolamine Level
- Reduced Malonaldehyde Levels
- Reduced Malondialdehyde Level
- Reduced Medical Assessment Score
- Reduced Mitogen-Activated Protein Kinase Kinase 3 Level
- Reduced Mitogen-Activated Protein Kinase Kinase 4 Level
- Reduced Monocyte Chemoattractant Protein-1 Level
- Reduced Monocyte Chemotactic Protein-1 Level
- Reduced N-acetylaspartate Level
- Reduced NADPH Oxidase Activity
- Reduced NF-kappaB Nuclear Translocation
- Reduced Neurodegeneration Symptoms
- Reduced Neurodegenerative Disease-Related Dysfunction
- Reduced Neuroinflammation
- Reduced Neuroinflammatory Markers
- Reduced Neurological Symptoms
- Reduced Neuronal Death
- Reduced Neuropeptide Y Level
- Reduced Neurotoxicity
- Reduced Nuclear Factor Erythroid 2-Related Factor 2 Level
- Reduced Nuclear Factor Kappa-B Level
- Reduced Oxidative Stress
- Reduced Oxidative Stress Index
- Reduced Oxidative Stress Marker Level
- Reduced Oxidative Stress Markers
- Reduced Oxidative Stress Score
- Reduced Oxidized Glutathione Level
- Reduced P3b Amplitude
- Reduced Plasma LPS Levels
- Reduced Polyamine Levels
- Reduced Prefrontal Cortex Activation
- Reduced Prefrontal Cortex Oxygen Saturation
- Reduced Prefrontal Cortex Oxygenated Hemoglobin
- Reduced Prefrontal Cortex Total Hemoglobin Level
- Reduced Pressure Injury Occurrence
- Reduced Pro-Inflammatory Factor TNF-α
- Reduced Pro-Inflammatory Fatty Acids
- Reduced Pro-inflammatory Cytokine Levels
- Reduced Pro-inflammatory to Anti-inflammatory Factor Ratio
- Reduced Proinflammatory Cytokines in Middle-aged Adults
- Reduced Proinflammatory Signaling
- Reduced Proportion of Volunteers with At Least One CID
- Reduced Protein Carbonyl Level
- Reduced Protein Damage
- Reduced Protein Oxidation
- Reduced Proteotoxicity
- Reduced Psychological Score
- Reduced Reaction Time
- Reduced Reactive Oxygen Species Formation
- Reduced Reactive Oxygen Species Generation
- Reduced Response Time
- Reduced Response Time on Flanker Task
- Reduced Retroactive Interference
- Reduced S-Adenosylmethionine Level
- Reduced Senescence-Associated Secretory Phenotype
- Reduced Serum BDNF Levels
- Reduced Serum Glutamate Levels
- Reduced Serum MDA Concentrations
- Reduced Serum Malondialdehyde Levels
- Reduced Set-Shifting Reversal Error
- Reduced Simple Reaction Time
- Reduced Soluble CD14
- Reduced Soluble Fas Level
- Reduced Soluble Fas/Fas Ligand Ratio
- Reduced Soluble Receptor of Advanced Glycation End Product Level
- Reduced Stroop Reaction Time
- Reduced Subjective Cognitive Decline
- Reduced TCM Syndrome Score
- Reduced Tau Phosphorylated at Threonine 181
- Reduced Tau Phosphorylated at Threonine 231
- Reduced Th17 Cell
- Reduced Timed Up and Go Test Time
- Reduced Total Antioxidant Capacity
- Reduced Total Tau Level
- Reduced Tower of London Test Start Time
- Reduced Trail Making Test Completion Time
- Reduced Urinary 8-Isoprostane Level
- Reduced Vascular Endothelial Growth Factor
- Reduced Vascular Endothelial Growth Factor Level
- Reduced Visual Reaction Time
- Reduced Washing Solution Volume
- Reduced White Matter Hyperintensity Severity
- Reduced cFos Expression in Brain Areas
- Regulated Blood miRNA Expression
- Regulated Microglial Activation
- Regulated Oxidative Stress
- Regulation of Neuroactive Ligand Receptor Interaction Pathway
- Reproduced Protective Effect via Extracellular Vesicles
- Restored Neurodegeneration-Associated Metabolic Alterations
- Restored SOD Activity Levels
- Similar Frequency of Adverse Events
- Slowed Brain Atrophy Progression
- Slowed Disease Progression
- Slowed Neuronal Damage Progression
- Slowed Progression of White Matter Hyperintensities
- Stabilized Cell Membranes
- Stabilized Disease Progression
- Stabilized Neurofilament Light Chain Level
- Stable Brain Metabolite Levels
- Supported Physiological Function in Elderly
- Unchanged Monocyte Chemoattractant Protein-1 Levels
- Worsened Alzheimer's Disease Assessment Scale
- Worsened Cognitive Function
- Worsened Inhibitory Control
- Worsened Motor Function