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Evidence-Based Supplement Research
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Valerian

Safety profile

5 studies reporting safety data

Across 5 clinical studies reporting safety data on valerian extract, no specific adverse events were found to be significantly increased compared to controls, and no serious adverse events were reported. Valerian was described as generally well tolerated in multiple studies, with side effects such as somnolence being mild and transient when observed. Two studies emphasized favorable overall tolerability, while one noted that changes in heart rate and blood pressure were less pronounced with valerian than with a placebo or diazepam.

Caveats: Most studies were not primarily designed to assess safety, and the evidence base is limited to a small number of trials, which may not capture rare adverse events. Long-term safety data are lacking, and generalizability to populations such as pregnant women or individuals with specific health conditions is not established.

Most-studied combinations with Valerian

most supplement research is combination research
Also studied with:St. John's Wort (2), Passion Flower (2), Lavender (3), Lemon Balm (3)

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