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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Bacillus coagulans

Safety profile

6 studies reporting safety data

Across 6 clinical studies, no adverse events were found to be increased with Bacillus coagulans supplementation. In 1 study, no significant difference was observed between the probiotic and control groups for specific safety outcomes such as diarrhoea recovery rate, duration, and fluid intake. The remaining 5 studies reported the probiotic as generally well tolerated, with statements including no serious adverse events, no reports of adverse reactions, and no statistically significant differences in adverse event analyses.

Caveats: The evidence base is limited; most studies provided only qualitative tolerability statements rather than quantitative safety data. Studies were likely powered for efficacy rather than safety, and long-term or population-specific safety is not established.

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